Nuclear receptors take center stage in Th17 cell-mediated autoimmunity

Liver X receptors (LXRs) are nuclear receptors involved in cholesterol homeostasis. Notably, they are also expressed by T cells and are involved in regulating T cell proliferation and differentiation. In this issue of the JCI, Cui et al. have elucidated the molecular mechanism underlying the effects...

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Bibliographic Details
Published in:The Journal of clinical investigation 2011-02, Vol.121 (2), p.519-521
Main Authors: Heller, Jennifer J, Qiu, Ju, Zhou, Liang
Format: Article
Language:English
Subjects:
Animals
Autoimmunity
Autoimmunity - immunology
Biomedical research
Cell Differentiation - immunology
Cell proliferation
Humans
Interleukin-17 - genetics
Interleukin-17 - immunology
Liver X Receptors
Mice
Orphan Nuclear Receptors - immunology
Physiological aspects
Properties
Receptors, Aryl Hydrocarbon - immunology
T cells
Th17 Cells - immunology
Th17 Cells - physiology
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Summary:Liver X receptors (LXRs) are nuclear receptors involved in cholesterol homeostasis. Notably, they are also expressed by T cells and are involved in regulating T cell proliferation and differentiation. In this issue of the JCI, Cui et al. have elucidated the molecular mechanism underlying the effects of LXR activation on a subset of T cells known as Th17 cells in mice and humans. Specifically, they showed that LXR-induced Srebp-1 inhibits Il17 transcription by binding to the Il17 promoter through interaction with the aryl hydrocarbon receptor (Ahr), a transcription factor known to enhance Th17 cell responses.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI45939