Effects of circadian disruption on the cardiometabolic system

The presence of day-night variations in cardiovascular and metabolic functioning is well known. However, only recently it has been shown that cardiovascular and metabolic processes are not only affected by the behavioral sleep/wake cycle but are partly under direct control of the master circadian pa...

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Bibliographic Details
Published in:Reviews in endocrine & metabolic disorders 2009-12, Vol.10 (4), p.245-260
Main Authors: Rüger, Melanie, Scheer, Frank A. J. L
Format: Article
Language:English
Subjects:
Animals
Cardiovascular System - metabolism
Cardiovascular System - radiation effects
Circadian Rhythm - physiology
Diabetes
Endocrinology
Humans
Internal Medicine
Light
Medicine
Medicine & Public Health
Melatonin - metabolism
Melatonin - physiology
Suprachiasmatic Nucleus - metabolism
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Summary:The presence of day-night variations in cardiovascular and metabolic functioning is well known. However, only recently it has been shown that cardiovascular and metabolic processes are not only affected by the behavioral sleep/wake cycle but are partly under direct control of the master circadian pacemaker located in the suprachiasmatic nucleus (SCN). Heart rate, cardiac autonomic activity, glucose metabolism and leptin—involved in appetite control—all show circadian variation (i.e., under constant behavioral and environmental conditions). This knowledge of behavioral vs. circadian modulation of cardiometabolic function is of clinical relevance given the morning peak in adverse cardiovascular incidents observed in epidemiological studies and given the increased risk for the development of diabetes, obesity, and cardiovascular disease in shift workers. We will review the evidence for circadian control of cardiometabolic functioning, as well its sensitivity to light and melatonin, and discuss potential implication for therapy.
ISSN:1389-9155
1573-2606
DOI:10.1007/s11154-009-9122-8