Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis

AIM： To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis （B. lactis） in an adoptive transfer model of colitis. METHODS： Donor and recipient mice received either B. lactis or bacterial culture medium as control （deMan Rogosa Sharpe） in drinking water for one week prior to t...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2011-01, Vol.17 (4), p.459-469
Main Authors: Philippe, David, Favre, Laurent, Foata, Francis, Adolfsson, Oskar, Perruisseau-Carrier, Genevieve, Vidal, Karine, Reuteler, Gloria, Dayer-Schneider, Johanna, Mueller, Christoph, Blum, Stéphanie
Format: Article
Language:English
Subjects:
Adoptive Transfer
Animals
Bifidobacterium - immunology
Biomarkers - metabolism
Body Weight
Colitis - immunology
Colitis - microbiology
Colitis - pathology
Disease Models, Animal
Feces - microbiology
Humans
Inflammation - drug therapy
Inflammation - immunology
Inflammation - microbiology
Mice
Mice, Inbred C57BL
Original
Probiotics - administration & dosage
Probiotics - therapeutic use
T-Lymphocytes - immunology
双歧杆菌
发病
小鼠
模型
炎症介质
球菌
结肠炎
调节性T细胞
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Summary:AIM： To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis （B. lactis） in an adoptive transfer model of colitis. METHODS： Donor and recipient mice received either B. lactis or bacterial culture medium as control （deMan Rogosa Sharpe） in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS： All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION： Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v17.i4.459