Congenital tuberculosis in premature twins after in vitro fertilisation

Genital tuberculosis is a major cause of infertility in countries where tuberculosis is endemic. With recent advances in assisted reproductive technology, women with tuberculous endometritis may become pregnant and ultimately have children with congenital tuberculosis. In vitro fertilisation represe...

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Bibliographic Details
Published in:BMJ case reports 2009, Vol.2009 (sep06 2), p.bcr0520091894-bcr0520091894
Main Authors: Altunhan, Hüseyin, Keser, Melike, Pekcan, Sevgi, Ural, Onur, Örs, Rahmi
Format: Article
Language:English
Subjects:
12 Months
Abdomen
Asia
Babies
Breastfeeding & lactation
Congenital diseases
Female
Fetuses
Granulomas
HIV
Human immunodeficiency virus
In vitro fertilization
Infections
Lungs
Magnetic resonance imaging
Male
Meningitis
Pregnancy
Rare Disease
Sepsis
Tomography
Tuberculosis
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Summary:Genital tuberculosis is a major cause of infertility in countries where tuberculosis is endemic. With recent advances in assisted reproductive technology, women with tuberculous endometritis may become pregnant and ultimately have children with congenital tuberculosis. In vitro fertilisation represents a useful treatment for infertility. Congenital tuberculosis is a rare and severe, rapidly progressive, disease. Making an early diagnosis of congenital tuberculosis is difficult, because it can mimic many neonatal illnesses. To the best of our knowledge, we report the first cases of premature twins with congenital tuberculosis following in vitro fertilisation. After the diagnosis of genital tuberculosis in the mother, the twins were screened and diagnosed for tuberculosis. The twins dramatically improved after anti-tuberculosis therapy. We also wish to draw attention to the importance of searching for genital tuberculosis as the possible cause of congenital infection, even if the mother is asymptomatic.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr.05.2009.1894