Teriparatide Therapy and Beta-Tricalcium Phosphate Enhance Scaffold Reconstruction of Mouse Femoral Defects

To investigate the efficacy of endocrine parathyroid hormone treatment on tissue-engineered bone regeneration, massive femoral defects in C57Bl/6 mice were reconstructed with either 100:0 or 85:15 poly-lactic acid (PLA)/beta-tricalcium phosphate (β-TCP) scaffolds (hereafter PLA or PLA/βTCP, respecti...

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Bibliographic Details
Published in:Tissue engineering. Part A 2011-02, Vol.17 (3-4), p.389-398
Main Authors: Jacobson, Justin A., Yanoso-Scholl, Laura, Reynolds, David G., Dadali, Tulin, Bradica, Gino, Bukata, Susan, Puzas, Edward J., Zuscik, Michael J., Rosier, Randy, O'Keefe, Regis J., Schwarz, Edward M., Awad, Hani A.
Format: Article
Language:English
Subjects:
Animals
Bone regeneration
Bone Substitutes - therapeutic use
Bones
Calcium phosphate
Calcium Phosphates - therapeutic use
Combined Modality Therapy
Endocrine therapy
Female
Femoral Fractures - pathology
Femoral Fractures - therapy
Femur
Health aspects
Medical examination
Mice
Mice, Inbred BALB C
Original
Original Articles
Parathyroid hormone
Rodents
Teriparatide - administration & dosage
Tissue engineering
Tissue Scaffolds
Treatment Outcome
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Summary:To investigate the efficacy of endocrine parathyroid hormone treatment on tissue-engineered bone regeneration, massive femoral defects in C57Bl/6 mice were reconstructed with either 100:0 or 85:15 poly-lactic acid (PLA)/beta-tricalcium phosphate (β-TCP) scaffolds (hereafter PLA or PLA/βTCP, respectively), which were fabricated with low porosity (
ISSN:1937-3341
1937-335X
DOI:10.1089/ten.tea.2010.0115