Are Statin Medications Associated with Lower Urinary Tract Symptoms in Men and Women? Results from the Boston Area Community Health (BACH) Survey

Purpose Statins may ameliorate lower urinary tract symptoms (LUTS) through anti-inflammatory or other pathways. We investigated the association between statin use and storage, voiding, and overall LUTS symptoms. Methods The Boston Area Community Health Survey is an epidemiologic study of Boston, MA...

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Bibliographic Details
Published in:Annals of epidemiology 2011-03, Vol.21 (3), p.149-155
Main Authors: Hall, Susan A., PhD, Chiu, Gretchen R., MS, Link, Carol L., PhD, Steers, William D., MD, Kupelian, Varant, PhD, McKinlay, John B., PhD
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Boston - epidemiology
Confidence Intervals
Epidemiology
Female
HMG-CoA
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Hypercholesterolemia - drug therapy
Internal Medicine
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Prevalence
Sex Factors
Statins
Urination Disorders
Urologic Diseases - epidemiology
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Summary:Purpose Statins may ameliorate lower urinary tract symptoms (LUTS) through anti-inflammatory or other pathways. We investigated the association between statin use and storage, voiding, and overall LUTS symptoms. Methods The Boston Area Community Health Survey is an epidemiologic study of Boston, MA residents (2301 men; 3202 women) 30–79 years of age. LUTS, voiding, and storage symptoms were ascertained through an interviewer-administered questionnaire and defined as scores of greater than or equal to 8, greater than or equal to 5, and greater than or equal to 4, respectively, on relevant components of the American Urologic Association Symptom Index. Participants were included if they had a history of provider-diagnosed high cholesterol or recently used statin medications (n = 1346). Associations were estimated using odds ratios (ORs) and 95% confidence intervals (CI) from multivariate logistic regression. Results In multivariate models, statin use had no association with LUTS (OR = 1.03, 95% CI: 0.70, 1.51) among women. No associations were observed for any LUTS among younger (
ISSN:1047-2797
1873-2585
DOI:10.1016/j.annepidem.2010.09.002