Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated with Malpighia emarginata Juice

Knowing that maternal diabetes is related to hyperglycemia and fetal hyperinsulinemia, which affect the lipid metabolism, the aim of this study was to evaluate the effects of Malpighia emarginata (acerola) juice on the glycemic and lipid profile of offspring of diabetic and nondiabetic Wistar rats....

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Bibliographic Details
Published in:Experimental diabetes research 2011-01, Vol.2011 (2011), p.1-6
Main Authors: Silva, Vanessa Sellis da, Oshiiwa, Marie, Martuchi, Karla Aparecida, Sazaki, Viviane, Palhares, Miréia, Spada, Ana Paula Machado, Barbalho, Sandra M., Damasceno, Débora C.
Format: Article
Language:English
Subjects:
Animals
Beverages
Blood Glucose - drug effects
Blood Glucose - metabolism
Care and treatment
Chemical properties
Diabetes
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - pathology
Diagnosis
Female
Health aspects
Lipid Metabolism - drug effects
Male
Malpighiaceae
Malpighiaceae - chemistry
Materia medica, Vegetable
Maternal Nutritional Physiological Phenomena - drug effects
Metabolome - drug effects
Plant extracts
Plant Extracts - pharmacology
Pregnancy
Pregnancy in Diabetics - pathology
Prenatal Exposure Delayed Effects - metabolism
Rats
Rats, Wistar
Streptozocin
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Summary:Knowing that maternal diabetes is related to hyperglycemia and fetal hyperinsulinemia, which affect the lipid metabolism, the aim of this study was to evaluate the effects of Malpighia emarginata (acerola) juice on the glycemic and lipid profile of offspring of diabetic and nondiabetic Wistar rats. The adult offspring of non-diabetic dams and of dams with severe streptozotocin-induced diabetes were divided into groups: G1, offspring (of control dams) treated with water, G2, offspring (of diabetic dams) treated with water, G3, male offspring (of control dams) treated with acerola juice, and G4, male offspring (of diabetic dams) treated with acerola juice. The offspring of diabetic dams treated with acerola juice showed significantly decreased levels of glucose, cholesterol, triglycerides, and increased HDL-c. The use of acerola juice is a potential strategy to aid in the prevention of DM and dyslipidemia and its complications or to act as an auxiliary in the treatment of these diseases.
ISSN:1687-5214
1687-5303
DOI:10.1155/2011/173647