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Electocardiographic findings in adult Nigerians with sickle cell anaemia
Cardiovascular system abnormalities are common causes of morbidity and mortality in sickle cell anaemia. The study aims at determining the pattern of electrocardiographic changes in adult Nigerian sickle cell anaemia patients. A descriptive cross sectional study was done on sixty sickle cell anaemia...
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Published in: | African health sciences 2010-09, Vol.10 (3), p.235-241 |
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creator | Oguanobi, N I Onwubere, B J C Ike, S O Anisiuba, B C Ejim, E C Ibegbulam, O G |
description | Cardiovascular system abnormalities are common causes of morbidity and mortality in sickle cell anaemia.
The study aims at determining the pattern of electrocardiographic changes in adult Nigerian sickle cell anaemia patients.
A descriptive cross sectional study was done on sixty sickle cell anaemia patients seen at the adult sickle cell clinic of University of Nigeria Teaching Hospital (UNTH) Enugu, and sixty age and sex matched normal controls. All the subjects had clinical evaluation as well as electrocardiographic examination.
The mean heart rate, P-wave duration, P-wave dispersion, PR interval, QRS duration, QRS dispersion, QTc interval and QTc dispersion were significantly higher in the patients than in the control group. Electrocardiographic abnormalities identified by this study were: left ventricular hypertrophy (75%; 1.7%), left atrial enlargement (40%; 0%), biventricular hypertrophy (11%; 0), ST-segment elevation (10%; 0%) and increased P-wave and QTc dispersions. ST segment elevation was found more in patients with moderate and severe anaemia (P= 0.02, Spearman correlation r= 0.342; P= 0.007),
Sickle cell anaemia is associated with significant electrocardiographic abnormalities. Further prospective studies are recommended to evaluate the prognostic significance of the electrocardiographic intervals dispersion on the long term disease outcome in sickle cell anaemia. |
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The study aims at determining the pattern of electrocardiographic changes in adult Nigerian sickle cell anaemia patients.
A descriptive cross sectional study was done on sixty sickle cell anaemia patients seen at the adult sickle cell clinic of University of Nigeria Teaching Hospital (UNTH) Enugu, and sixty age and sex matched normal controls. All the subjects had clinical evaluation as well as electrocardiographic examination.
The mean heart rate, P-wave duration, P-wave dispersion, PR interval, QRS duration, QRS dispersion, QTc interval and QTc dispersion were significantly higher in the patients than in the control group. Electrocardiographic abnormalities identified by this study were: left ventricular hypertrophy (75%; 1.7%), left atrial enlargement (40%; 0%), biventricular hypertrophy (11%; 0), ST-segment elevation (10%; 0%) and increased P-wave and QTc dispersions. ST segment elevation was found more in patients with moderate and severe anaemia (P= 0.02, Spearman correlation r= 0.342; P= 0.007),
Sickle cell anaemia is associated with significant electrocardiographic abnormalities. Further prospective studies are recommended to evaluate the prognostic significance of the electrocardiographic intervals dispersion on the long term disease outcome in sickle cell anaemia.</description><identifier>ISSN: 1680-6905</identifier><identifier>EISSN: 1729-0503</identifier><identifier>PMID: 21327134</identifier><language>eng</language><publisher>Uganda: Makerere Medical School</publisher><subject>Adolescent ; Adult ; African Continental Ancestry Group ; Anemia, Sickle Cell - complications ; Anemia, Sickle Cell - epidemiology ; Cardiovascular Abnormalities - complications ; Cardiovascular Abnormalities - epidemiology ; Cardiovascular Abnormalities - physiopathology ; Cardiovascular Diseases - etiology ; Case-Control Studies ; Cross-Sectional Studies ; Electrocardiography - methods ; Female ; Hematocrit ; Hospitals, Teaching ; Humans ; Male ; Middle Aged ; Nigeria - epidemiology ; Original ; Prevalence ; Young Adult</subject><ispartof>African health sciences, 2010-09, Vol.10 (3), p.235-241</ispartof><rights>Copyright © Makerere Medical School, Uganda 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035954/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035954/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21327134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oguanobi, N I</creatorcontrib><creatorcontrib>Onwubere, B J C</creatorcontrib><creatorcontrib>Ike, S O</creatorcontrib><creatorcontrib>Anisiuba, B C</creatorcontrib><creatorcontrib>Ejim, E C</creatorcontrib><creatorcontrib>Ibegbulam, O G</creatorcontrib><title>Electocardiographic findings in adult Nigerians with sickle cell anaemia</title><title>African health sciences</title><addtitle>Afr Health Sci</addtitle><description>Cardiovascular system abnormalities are common causes of morbidity and mortality in sickle cell anaemia.
The study aims at determining the pattern of electrocardiographic changes in adult Nigerian sickle cell anaemia patients.
A descriptive cross sectional study was done on sixty sickle cell anaemia patients seen at the adult sickle cell clinic of University of Nigeria Teaching Hospital (UNTH) Enugu, and sixty age and sex matched normal controls. All the subjects had clinical evaluation as well as electrocardiographic examination.
The mean heart rate, P-wave duration, P-wave dispersion, PR interval, QRS duration, QRS dispersion, QTc interval and QTc dispersion were significantly higher in the patients than in the control group. Electrocardiographic abnormalities identified by this study were: left ventricular hypertrophy (75%; 1.7%), left atrial enlargement (40%; 0%), biventricular hypertrophy (11%; 0), ST-segment elevation (10%; 0%) and increased P-wave and QTc dispersions. ST segment elevation was found more in patients with moderate and severe anaemia (P= 0.02, Spearman correlation r= 0.342; P= 0.007),
Sickle cell anaemia is associated with significant electrocardiographic abnormalities. Further prospective studies are recommended to evaluate the prognostic significance of the electrocardiographic intervals dispersion on the long term disease outcome in sickle cell anaemia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>African Continental Ancestry Group</subject><subject>Anemia, Sickle Cell - complications</subject><subject>Anemia, Sickle Cell - epidemiology</subject><subject>Cardiovascular Abnormalities - complications</subject><subject>Cardiovascular Abnormalities - epidemiology</subject><subject>Cardiovascular Abnormalities - physiopathology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Electrocardiography - methods</subject><subject>Female</subject><subject>Hematocrit</subject><subject>Hospitals, Teaching</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nigeria - epidemiology</subject><subject>Original</subject><subject>Prevalence</subject><subject>Young Adult</subject><issn>1680-6905</issn><issn>1729-0503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNpVkF1LwzAUhoMobk7_guTOq0I-mrS5EWRMJwy90euQr3bRNK1Jq_jvN3GKXp0XzsvzcM4RmOOKiAIxRI_3mdeo4AKxGTjL-QUhwrHAp2BGMCUVpuUcrFfBmbE3Klnft0kNW29g46P1sc3QR6jsFEb44FuXvIoZfvhxC7M3r8FB40KAKirXeXUOThoVsrs4zAV4vl09LdfF5vHufnmzKQbC2VgQoa0hDXW4QZgJQ4yypsaUloJTYnXJtaVVhY3RdUNo5WqlrRCaE8OQpZwuwPU3d5h056xxcUwqyCH5TqVP2Ssv_2-i38q2f5cUUSZYuQdcHQCpf5tcHmXn89clKrp-yrJmRKBakGrfvPyr-nX8fI_uAHQkbmI</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Oguanobi, N I</creator><creator>Onwubere, B J C</creator><creator>Ike, S O</creator><creator>Anisiuba, B C</creator><creator>Ejim, E C</creator><creator>Ibegbulam, O G</creator><general>Makerere Medical School</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100901</creationdate><title>Electocardiographic findings in adult Nigerians with sickle cell anaemia</title><author>Oguanobi, N I ; Onwubere, B J C ; Ike, S O ; Anisiuba, B C ; Ejim, E C ; Ibegbulam, O G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p265t-29bdc2f3e1f0159c2cadc813349632db46bd3771ccb8f237e8abd99b62c50d363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>African Continental Ancestry Group</topic><topic>Anemia, Sickle Cell - complications</topic><topic>Anemia, Sickle Cell - epidemiology</topic><topic>Cardiovascular Abnormalities - complications</topic><topic>Cardiovascular Abnormalities - epidemiology</topic><topic>Cardiovascular Abnormalities - physiopathology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Electrocardiography - methods</topic><topic>Female</topic><topic>Hematocrit</topic><topic>Hospitals, Teaching</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nigeria - epidemiology</topic><topic>Original</topic><topic>Prevalence</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oguanobi, N I</creatorcontrib><creatorcontrib>Onwubere, B J C</creatorcontrib><creatorcontrib>Ike, S O</creatorcontrib><creatorcontrib>Anisiuba, B C</creatorcontrib><creatorcontrib>Ejim, E C</creatorcontrib><creatorcontrib>Ibegbulam, O G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>African health sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oguanobi, N I</au><au>Onwubere, B J C</au><au>Ike, S O</au><au>Anisiuba, B C</au><au>Ejim, E C</au><au>Ibegbulam, O G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electocardiographic findings in adult Nigerians with sickle cell anaemia</atitle><jtitle>African health sciences</jtitle><addtitle>Afr Health Sci</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>10</volume><issue>3</issue><spage>235</spage><epage>241</epage><pages>235-241</pages><issn>1680-6905</issn><eissn>1729-0503</eissn><abstract>Cardiovascular system abnormalities are common causes of morbidity and mortality in sickle cell anaemia.
The study aims at determining the pattern of electrocardiographic changes in adult Nigerian sickle cell anaemia patients.
A descriptive cross sectional study was done on sixty sickle cell anaemia patients seen at the adult sickle cell clinic of University of Nigeria Teaching Hospital (UNTH) Enugu, and sixty age and sex matched normal controls. All the subjects had clinical evaluation as well as electrocardiographic examination.
The mean heart rate, P-wave duration, P-wave dispersion, PR interval, QRS duration, QRS dispersion, QTc interval and QTc dispersion were significantly higher in the patients than in the control group. Electrocardiographic abnormalities identified by this study were: left ventricular hypertrophy (75%; 1.7%), left atrial enlargement (40%; 0%), biventricular hypertrophy (11%; 0), ST-segment elevation (10%; 0%) and increased P-wave and QTc dispersions. ST segment elevation was found more in patients with moderate and severe anaemia (P= 0.02, Spearman correlation r= 0.342; P= 0.007),
Sickle cell anaemia is associated with significant electrocardiographic abnormalities. Further prospective studies are recommended to evaluate the prognostic significance of the electrocardiographic intervals dispersion on the long term disease outcome in sickle cell anaemia.</abstract><cop>Uganda</cop><pub>Makerere Medical School</pub><pmid>21327134</pmid><tpages>7</tpages></addata></record> |
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subjects | Adolescent Adult African Continental Ancestry Group Anemia, Sickle Cell - complications Anemia, Sickle Cell - epidemiology Cardiovascular Abnormalities - complications Cardiovascular Abnormalities - epidemiology Cardiovascular Abnormalities - physiopathology Cardiovascular Diseases - etiology Case-Control Studies Cross-Sectional Studies Electrocardiography - methods Female Hematocrit Hospitals, Teaching Humans Male Middle Aged Nigeria - epidemiology Original Prevalence Young Adult |
title | Electocardiographic findings in adult Nigerians with sickle cell anaemia |
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