Community Exposure to Perfluorooctanoate: Relationships Between Serum Concentrations and Exposure Sources

Objective: The objective of this study was to determine serum (perfluorooctanoate [PFOA]) in residents near a fluoropolymer production facility: the contributions from air, water, and occupational exposures, personal and dietary habits, and relationships to age and gender. Methods: The authors condu...

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Bibliographic Details
Published in:Journal of occupational and environmental medicine 2006-08, Vol.48 (8), p.759-770
Main Authors: Emmett, Edward Anthony, Shofer, Frances Susan, Zhang, Hong, Freeman, David, Desai, Chintan, Shaw, Leslie Michael
Format: Article
Language:English
Subjects:
Adult
Air Pollutants - blood
Air Pollutants - poisoning
Biological and medical sciences
Caprylates - blood
Caprylates - poisoning
Chemical and industrial products toxicology. Toxic occupational diseases
Chemicals
Environmental Exposure - analysis
Environmental Monitoring - methods
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Female
Fluorocarbons - blood
Fluorocarbons - poisoning
Hazardous materials
Health hazards
Human exposure
Humans
Male
Medical sciences
Multivariate Analysis
Residence Characteristics
Surveys and Questionnaires
Toxicology
Various organic compounds
Water Pollutants, Chemical - blood
Water Pollutants, Chemical - poisoning
Water pollution
Water Supply
West Virginia
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Summary:Objective: The objective of this study was to determine serum (perfluorooctanoate [PFOA]) in residents near a fluoropolymer production facility: the contributions from air, water, and occupational exposures, personal and dietary habits, and relationships to age and gender. Methods: The authors conducted questionnaire and serum PFOA measurements in a stratified random sample and volunteers residing in locations with the same residential water supply but with higher and lower potential air PFOA exposure. Results: Serum (PFOA) greatly exceeded general population medians. Occupational exposure from production processes using PFOA and residential water had additive effects; no other occupations contributed. Serum (PFOA) depended on the source of residential dunking water, and not potential air exposure. For public water users, the best-fit model included age, tap water dunks per day, servings of home-grown fruit and vegetables, an carbon filter use. Conclusions: Residential water source was the primar determinant of serum (PFOA).
ISSN:1076-2752
1536-5948
DOI:10.1097/01.jom.0000232486.07658.74