Cross-Sectional versus Longitudinal Associations of Lean and Fat Mass with pQCT Bone Outcomes in Children

• Published in: The journal of clinical endocrinology and metabolism 2011-01, Vol.96 (1), p.106-114
• Main Authors: Wey, Howard E, Binkley, Teresa L, Beare, Tianna M, Wey, Christine L, Specker, Bonny L
• Format: Article
• Language: English
• Subjects: Absorptiometry, Photon; Adipose Tissue - diagnostic imaging; Adolescent; Analysis of Variance; Biological and medical sciences; Body Composition - physiology; Bone Density - physiology; Chi-Square Distribution; Child; Endocrinopathies; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Humans; Longitudinal Studies; Male; Medical sciences; Motor Activity - physiology; Original; Radius - diagnostic imaging; Sex Factors; Tomography, X-Ray Computed; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.2010-0889

Context: Cross-sectional associations for lean mass (LM) and fat mass (FM) with bone may not reflect longitudinal associations. Objective: Cross-sectional and longitudinal associations of LM and FM with radial bone measurements in children were compared. Design and Participants: We conducted a longitudinal study on 370 (232 females) children, 8–18 yr of age. Main Outcome Measures: LM and FM were measured by dual-energy absorptiometry. Peripheral quantitative computed tomography at the 4% radius (4R) and 20% radius (20R) measured bone mineral content (BMC), volumetric bone mineral density (vBMD), area, and strength [polar stress strain index (pSSI)]. Results: Males at 20R had negative FM cross-sectional and longitudinal associations with cortical area and BMC and pSSI (P < 0.02); negative cross-sectional association with total area (P < 0.001); and negative longitudinal association with cortical thickness (P < 0.001). Females at 20R had FM cross-sectional association with total area, cortical BMC, and pSSI and longitudinal associations with cortical BMC and area, vBMD, and pSSI that went from positive to negative with age and, in some cases, varied with menarche. Both sexes at 4R had a negative FM cross-sectional association with BMC and area (P < 0.001) but negative longitudinal association with vBMD (P < 0.05). LM associations with bone outcomes were generally positive, except for negative longitudinal associations with cortical BMC and vBMD in young females (P < 0.01). LM associations were greater magnitude than FM associations and often depended on age. Conclusions: For males and older females, cross-sectional associations indicated a reduced bone size with higher FM, whereas longitudinal associations showed a decrease in cortical area without changes in bone size. LM was positively associated with BMC and area. Longitudinal associations of fat mass with bone are distinct from cross-sectional associations, and negatively impact bone growth.