Exploitation of the Ubiquitin System by Invading Bacteria

A variety of bacterial intracellular pathogens target the host cell ubiquitin system during invasion, a process that involves transient but fundamental changes in the actin cytoskeleton and plasma membrane. These changes are induced by bacterial proteins, which can be surface associated, secreted or...

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Bibliographic Details
Published in:Traffic (Copenhagen, Denmark) Denmark), 2011-02, Vol.12 (2), p.162-169
Main Author: Steele-Mortimer, Olivia
Format: Article
Language:English
Subjects:
Actin
Actins - metabolism
Bacteria - metabolism
Cell Membrane - metabolism
Cytoskeleton
Cytoskeleton - metabolism
effector
Humans
intracellular
Listeria
Listeria monocytogenes
Pathogens
Plasma membranes
Salmonella
Salmonella enterica
type III secretion system
Ubiquitin
Ubiquitin - metabolism
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Summary:A variety of bacterial intracellular pathogens target the host cell ubiquitin system during invasion, a process that involves transient but fundamental changes in the actin cytoskeleton and plasma membrane. These changes are induced by bacterial proteins, which can be surface associated, secreted or injected directly into the host cell. Here, the invasion strategies of two extensively studied intracellular bacteria, Salmonella enterica serovar Typhimurium and Listeria monocytogenes, are used to illustrate some of the diverse ways by which bacterial pathogens intersect the host cell ubiquitin pathway.
ISSN:1398-9219
1600-0854
DOI:10.1111/j.1600-0854.2010.01137.x