A population-based case-crossover study of polyethylene glycol use and acute renal failure risk in the elderly

• Published in: World journal of gastroenterology : WJG 2011-02, Vol.17 (5), p.651-656
• Main Authors: Choi, Nam-Kyong, Chang, Yoosoo, Jung, Sun-Young, Choi, Yu-Kyong, Lee, Joongyub, Lee, Jin-Ho, Kim, Ju-Young, Park, Byung-Joo
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury - etiology; Aged; Aged, 80 and over; Brief; Case-Control Studies; Cathartics - adverse effects; Colonoscopy; Cross-Over Studies; Databases, Factual; Female; Humans; Insurance Claim Review; logistic回归分析; Male; Polyethylene Glycols - adverse effects; Republic of Korea; Risk Factors; 中老年人; 人群; 急性肾功能衰竭; 控制窗口; 聚乙二醇; 血管紧张素转换酶抑制剂; 风险
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v17.i5.651

AIM： To evaluate the possibility of an association be-tween polyethylene glycol （PEG） and acute renal failure （ARF） in elderly patients using a health insurance claims database. METHODS： We conducted a population-based casecrossover study using information obtained from Korean Health Insurance Review and Assessment Service （HIRA） claims from January 1, 2005 to December 31, 2005 （Seoul, Korea）. The study population consisted of elderly patients who received PEG prior to experiencing their first ARF-related hospitalization from April 1, 2005 to Decem- ber 31, 2005. For each patient, one case and two control periods were matched. PEG use in a 2- or 4-wk window period prior to hospitalization for ARF was compared with PEG use in two earlier 2- or 4-wk control window periods. Conditional logistic regression analysis was used to estimate odds ratios （ORs） and 95% CI, adjusting for concomitant uses of diuretics, angiotensin converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, antibiotics, anti-cancer drugs, and contrast media. RESULTS： Within the HIRA database which contained 1093 262 elderly patients, 1156 hospitalized ARF cases were identified. Among these cases, PEG was prescribed to 17 （1.5%） patients before hospitalization. The adjusted ORs when applying the 2- and 4-wk window periods were 0.4 （95% CI： 0.03-5.24） and 2.1 （95% CI： 0.16-27.78）, respectively. CONCLUSION： No increased risk of ARF was found in elderly PEG users. However, based on the limited number of study subjects, further analysis should be performed to confirm these results.