NF-κB, Inflammation, and Metabolic Disease

Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis have been viewed historically as lipid storage disorders brought about by overnutrition. It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation, and development of me...

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Bibliographic Details
Published in:Cell metabolism 2011-01, Vol.13 (1), p.11-22
Main Authors: Baker, Rebecca G., Hayden, Matthew S., Ghosh, Sankar
Format: Article
Language:English
Subjects:
Animals
Humans
Inflammation - genetics
Inflammation - physiopathology
Inflammation Mediators - immunology
Inflammation Mediators - metabolism
Macrophages - immunology
Macrophages - pathology
Metabolic Diseases - genetics
Metabolic Diseases - immunology
Metabolic Diseases - metabolism
Metabolic Diseases - physiopathology
NF-kappa B - antagonists & inhibitors
NF-kappa B - immunology
NF-kappa B - physiology
NF-kappaB-Inducing Kinase
Protein Serine-Threonine Kinases - antagonists & inhibitors
Protein Serine-Threonine Kinases - physiology
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Summary:Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis have been viewed historically as lipid storage disorders brought about by overnutrition. It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation, and development of metabolic diseases. Consistent with its central role in coordinating inflammatory responses, numerous recent studies have implicated the transcription factor NF-κB in the development of such diseases, thereby further establishing inflammation as a critical factor in their etiology and offering hope for the development of new therapeutic approaches for their treatment.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2010.12.008