Assessment of bone remodelling in childhood-onset systemic lupus erythematosus

To identify predictors of bone remodelling in children and young adults with SLE. Ninety subjects with SLE aged 8-22 years underwent yearly measurements of height, bone age, bone turnover markers, serum Type I IFNs, SLEDAI and BMD. Predictors of bone turnover were examined using serum osteocalcin as...

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Published in:Rheumatology (Oxford, England) England), 2011-03, Vol.50 (3), p.611-619
Main Authors: BAKER-LEPAIN, Julie C, NAKAMURA, Mary C, SHEPHERD, John, VON SCHEVEN, Emily
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Biological and medical sciences
Body Mass Index
Bone Remodeling
Child
Clinical Science
Diseases of the osteoarticular system
Female
Fundamental and applied biological sciences. Psychology
Humans
Interferon-beta - blood
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - physiopathology
Male
Medical sciences
Predictive Value of Tests
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Severity of Illness Index
Skeleton and joints
Vertebrates: osteoarticular system, musculoskeletal system
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Summary:To identify predictors of bone remodelling in children and young adults with SLE. Ninety subjects with SLE aged 8-22 years underwent yearly measurements of height, bone age, bone turnover markers, serum Type I IFNs, SLEDAI and BMD. Predictors of bone turnover were examined using serum osteocalcin as a marker of bone formation and both serum tartrate-resistant acid phosphatase (TRAP) and urine N-telopeptide (NTx) as markers of bone resorption. Subjects demonstrated short stature, high BMI and bone age delay. A spine BMD Z-score of less than -2.0 was seen in 16.1% of subject visits. Serum osteocalcin was negatively correlated with glucocorticoid dose (Spearman rank correlation coefficient R = -0.34, P 
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/keq307