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Assessment of bone remodelling in childhood-onset systemic lupus erythematosus
To identify predictors of bone remodelling in children and young adults with SLE. Ninety subjects with SLE aged 8-22 years underwent yearly measurements of height, bone age, bone turnover markers, serum Type I IFNs, SLEDAI and BMD. Predictors of bone turnover were examined using serum osteocalcin as...
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| Published in: | Rheumatology (Oxford, England) England), 2011-03, Vol.50 (3), p.611-619 |
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| creator | BAKER-LEPAIN, Julie C NAKAMURA, Mary C SHEPHERD, John VON SCHEVEN, Emily |
| description | To identify predictors of bone remodelling in children and young adults with SLE.
Ninety subjects with SLE aged 8-22 years underwent yearly measurements of height, bone age, bone turnover markers, serum Type I IFNs, SLEDAI and BMD. Predictors of bone turnover were examined using serum osteocalcin as a marker of bone formation and both serum tartrate-resistant acid phosphatase (TRAP) and urine N-telopeptide (NTx) as markers of bone resorption.
Subjects demonstrated short stature, high BMI and bone age delay. A spine BMD Z-score of less than -2.0 was seen in 16.1% of subject visits. Serum osteocalcin was negatively correlated with glucocorticoid dose (Spearman rank correlation coefficient R = -0.34, P |
| doi_str_mv | 10.1093/rheumatology/keq307 |
| format | article |
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Ninety subjects with SLE aged 8-22 years underwent yearly measurements of height, bone age, bone turnover markers, serum Type I IFNs, SLEDAI and BMD. Predictors of bone turnover were examined using serum osteocalcin as a marker of bone formation and both serum tartrate-resistant acid phosphatase (TRAP) and urine N-telopeptide (NTx) as markers of bone resorption.
Subjects demonstrated short stature, high BMI and bone age delay. A spine BMD Z-score of less than -2.0 was seen in 16.1% of subject visits. Serum osteocalcin was negatively correlated with glucocorticoid dose (Spearman rank correlation coefficient R = -0.34, P < 0.0001) but was not associated with SLEDAI after adjustment for confounders. Serum TRAP was negatively associated with SLEDAI, even after controlling for confounders (P = 0.04). Similar results were obtained for urine NTx. There was a negative association between TRAP and serum IFN-β (P = 0.03).
In this population of children and young adults with moderate lupus disease activity, glucocorticoid dose was a negative predictor of bone formation, whereas lupus disease activity was not. Interestingly, lupus disease activity was a negative predictor of bone resorption, suggesting that lupus disease activity is not the primary factor contributing to the bone deficits of childhood-onset SLE. The potential protective role of IFN-β and the effects of SLE treatment on bone loss require further study.</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/keq307</identifier><identifier>PMID: 21098573</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Age of Onset ; Biological and medical sciences ; Body Mass Index ; Bone Remodeling ; Child ; Clinical Science ; Diseases of the osteoarticular system ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Interferon-beta - blood ; Lupus Erythematosus, Systemic - blood ; Lupus Erythematosus, Systemic - physiopathology ; Male ; Medical sciences ; Predictive Value of Tests ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Severity of Illness Index ; Skeleton and joints ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Rheumatology (Oxford, England), 2011-03, Vol.50 (3), p.611-619</ispartof><rights>2015 INIST-CNRS</rights><rights>The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-dd8781d33ebe87491e06dd376663731ac29b19eabf7745579c33df8a5e5e402a3</citedby><cites>FETCH-LOGICAL-c466t-dd8781d33ebe87491e06dd376663731ac29b19eabf7745579c33df8a5e5e402a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27900,27901</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23933182$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21098573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BAKER-LEPAIN, Julie C</creatorcontrib><creatorcontrib>NAKAMURA, Mary C</creatorcontrib><creatorcontrib>SHEPHERD, John</creatorcontrib><creatorcontrib>VON SCHEVEN, Emily</creatorcontrib><title>Assessment of bone remodelling in childhood-onset systemic lupus erythematosus</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>To identify predictors of bone remodelling in children and young adults with SLE.
Ninety subjects with SLE aged 8-22 years underwent yearly measurements of height, bone age, bone turnover markers, serum Type I IFNs, SLEDAI and BMD. Predictors of bone turnover were examined using serum osteocalcin as a marker of bone formation and both serum tartrate-resistant acid phosphatase (TRAP) and urine N-telopeptide (NTx) as markers of bone resorption.
Subjects demonstrated short stature, high BMI and bone age delay. A spine BMD Z-score of less than -2.0 was seen in 16.1% of subject visits. Serum osteocalcin was negatively correlated with glucocorticoid dose (Spearman rank correlation coefficient R = -0.34, P < 0.0001) but was not associated with SLEDAI after adjustment for confounders. Serum TRAP was negatively associated with SLEDAI, even after controlling for confounders (P = 0.04). Similar results were obtained for urine NTx. There was a negative association between TRAP and serum IFN-β (P = 0.03).
In this population of children and young adults with moderate lupus disease activity, glucocorticoid dose was a negative predictor of bone formation, whereas lupus disease activity was not. Interestingly, lupus disease activity was a negative predictor of bone resorption, suggesting that lupus disease activity is not the primary factor contributing to the bone deficits of childhood-onset SLE. The potential protective role of IFN-β and the effects of SLE treatment on bone loss require further study.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Bone Remodeling</subject><subject>Child</subject><subject>Clinical Science</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Interferon-beta - blood</subject><subject>Lupus Erythematosus, Systemic - blood</subject><subject>Lupus Erythematosus, Systemic - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Predictive Value of Tests</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Severity of Illness Index</subject><subject>Skeleton and joints</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>1462-0324</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkU1r3DAQhkVpadK0v6BQfCk9uZE0smRfCiH0C0JzSc9ClsZrtba10diF_ff1stttcspJA3rm4R1ext4K_lHwBi5zj8vo5jSkze7yN94DN8_YuVBalhxAPj_NUp2xV0S_OOeVgPolO5OroK4MnLMfV0RINOI0F6kr2jRhkXFMAYchTpsiToXv4xD6lEKZJsK5oB3NOEZfDMt2oQLzbu5xH4QWes1edG4gfHN8L9jPL5_vrr-VN7dfv19f3ZReaT2XIdSmFgEAW6yNagRyHQIYrTUYEM7LphUNurYzRlWVaTxA6GpXYYWKSwcX7NPBu13aEYNf42c32G2Oo8s7m1y0j3-m2NtN-mOBKymrahV8OApyul-QZjtG8uvRbsK0kG24UtpoqZ8k6wqUgYbvnXAgfU5EGbtTHsHtvjL7sDJ7qGzdevfwlNPOv45W4P0RcOTd0GU3-Uj_OWgARC3hL0rapok</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>BAKER-LEPAIN, Julie C</creator><creator>NAKAMURA, Mary C</creator><creator>SHEPHERD, John</creator><creator>VON SCHEVEN, Emily</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope><scope>5PM</scope></search><sort><creationdate>20110301</creationdate><title>Assessment of bone remodelling in childhood-onset systemic lupus erythematosus</title><author>BAKER-LEPAIN, Julie C ; NAKAMURA, Mary C ; SHEPHERD, John ; VON SCHEVEN, Emily</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-dd8781d33ebe87491e06dd376663731ac29b19eabf7745579c33df8a5e5e402a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Bone Remodeling</topic><topic>Child</topic><topic>Clinical Science</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Interferon-beta - blood</topic><topic>Lupus Erythematosus, Systemic - blood</topic><topic>Lupus Erythematosus, Systemic - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Predictive Value of Tests</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Severity of Illness Index</topic><topic>Skeleton and joints</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BAKER-LEPAIN, Julie C</creatorcontrib><creatorcontrib>NAKAMURA, Mary C</creatorcontrib><creatorcontrib>SHEPHERD, John</creatorcontrib><creatorcontrib>VON SCHEVEN, Emily</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BAKER-LEPAIN, Julie C</au><au>NAKAMURA, Mary C</au><au>SHEPHERD, John</au><au>VON SCHEVEN, Emily</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of bone remodelling in childhood-onset systemic lupus erythematosus</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology (Oxford)</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>50</volume><issue>3</issue><spage>611</spage><epage>619</epage><pages>611-619</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><abstract>To identify predictors of bone remodelling in children and young adults with SLE.
Ninety subjects with SLE aged 8-22 years underwent yearly measurements of height, bone age, bone turnover markers, serum Type I IFNs, SLEDAI and BMD. Predictors of bone turnover were examined using serum osteocalcin as a marker of bone formation and both serum tartrate-resistant acid phosphatase (TRAP) and urine N-telopeptide (NTx) as markers of bone resorption.
Subjects demonstrated short stature, high BMI and bone age delay. A spine BMD Z-score of less than -2.0 was seen in 16.1% of subject visits. Serum osteocalcin was negatively correlated with glucocorticoid dose (Spearman rank correlation coefficient R = -0.34, P < 0.0001) but was not associated with SLEDAI after adjustment for confounders. Serum TRAP was negatively associated with SLEDAI, even after controlling for confounders (P = 0.04). Similar results were obtained for urine NTx. There was a negative association between TRAP and serum IFN-β (P = 0.03).
In this population of children and young adults with moderate lupus disease activity, glucocorticoid dose was a negative predictor of bone formation, whereas lupus disease activity was not. Interestingly, lupus disease activity was a negative predictor of bone resorption, suggesting that lupus disease activity is not the primary factor contributing to the bone deficits of childhood-onset SLE. The potential protective role of IFN-β and the effects of SLE treatment on bone loss require further study.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>21098573</pmid><doi>10.1093/rheumatology/keq307</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Rheumatology (Oxford, England), 2011-03, Vol.50 (3), p.611-619 |
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| source | Oxford Journals Online; Alma/SFX Local Collection |
| subjects | Adolescent Adult Age of Onset Biological and medical sciences Body Mass Index Bone Remodeling Child Clinical Science Diseases of the osteoarticular system Female Fundamental and applied biological sciences. Psychology Humans Interferon-beta - blood Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - physiopathology Male Medical sciences Predictive Value of Tests Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Severity of Illness Index Skeleton and joints Vertebrates: osteoarticular system, musculoskeletal system |
| title | Assessment of bone remodelling in childhood-onset systemic lupus erythematosus |
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