Mechanical signal influence on mesenchymal stem cell fate is enhanced by incorporation of refractory periods into the loading regimen

Abstract Mechanical signals of both low and high intensity are inhibitory to fat and anabolic to bone in vivo, and have been shown to directly affect mesenchymal stem cell pools from which fat and bone precursors emerge. To identify an idealized mechanical regimen which can regulate MSC fate, low in...

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Bibliographic Details
Published in:Journal of biomechanics 2011-02, Vol.44 (4), p.593-599
Main Authors: Sen, Buer, Xie, Zhihui, Case, Natasha, Styner, Maya, Rubin, Clinton T, Rubin, Janet
Format: Article
Language:English
Subjects:
Adipocytes - cytology
Adipocytes - physiology
Adipogenesis
Adipogenesis - physiology
Animals
Biological and medical sciences
Biomechanics. Biorheology
Cell Differentiation
Cell Line
Fundamental and applied biological sciences. Psychology
Influence
Insulin
Mechanotransduction
Mechanotransduction, Cellular - physiology
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - physiology
Mice
Obesity
Osteoblastogenesis
Physical Medicine and Rehabilitation
Stem cells
Stress, Mechanical
Tissues, organs and organisms biophysics
β-catenin
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Summary:Abstract Mechanical signals of both low and high intensity are inhibitory to fat and anabolic to bone in vivo, and have been shown to directly affect mesenchymal stem cell pools from which fat and bone precursors emerge. To identify an idealized mechanical regimen which can regulate MSC fate, low intensity vibration (LIV;
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2010.11.022