Creation of a CT Image Library for the Lung Screening Study of the National Lung Screening Trial

• Published in: Journal of digital imaging 2007-03, Vol.20 (1), p.23-31
• Main Authors: Clark, K W, Gierada, D S, Moore, S M, Maffitt, D R, Koppel, P, Phillips, S R, Prior, F W
• Format: Article
• Language: English
• Subjects: Clinical Protocols; Computer Communication Networks; Humans; Lung - diagnostic imaging; Lung Neoplasms - diagnosis; Mass Screening - standards; Radiographic Image Enhancement - instrumentation; Radiographic Image Enhancement - methods; Radiology Information Systems; Tomography, X-Ray Computed - classification; Tomography, X-Ray Computed - instrumentation; Tomography, X-Ray Computed - methods; United States
• ISSN: 0897-1889; 1618-727X
• DOI: 10.1007/s10278-006-0589-5

The CT Image Library (CTIL) of the Lung Screening Study (LSS) network of the National Lung Screening Trial (NLST) consists of up to three annual screens using CT imaging from each of 17,308 participants with a significant history of smoking but no evidence of cancer at trial enrollment (Fall 2002-Spring 2004). Screens performed at numerous medical centers associated with 10 LSS-NLST screening centers are deidentified of protected health information and delivered to the CTIL via DVD, external hard disk, or Internet/Virtual Private Network transmission. The collection will be completed in late 2006. The CTIL is of potential interest to clinical researchers and software developers of nodule detection algorithms. Its attractiveness lies in its very specific, well-defined patient population, scanned via a common CT protocol, and in its collection of evenly spaced serial screens. In this work, we describe the technical details of the CTIL collection process from screening center retrieval through library storage.