Genetics of Alzheimer disease

Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals. Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances. Three causative genes have...

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Bibliographic Details
Published in:Journal of geriatric psychiatry and neurology 2010-12, Vol.23 (4), p.213-227
Main Authors: Bekris, Lynn M, Yu, Chang-En, Bird, Thomas D, Tsuang, Debby W
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging - genetics
Aging - pathology
Aging - psychology
Alleles
Alzheimer Disease - diagnosis
Alzheimer Disease - epidemiology
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Amyloid beta-Protein Precursor - genetics
Animals
Apolipoproteins E - genetics
Disease Models, Animal
Genetic Counseling
Genetic Predisposition to Disease
Genetic Testing
Genotype
Humans
Presenilin-1 - genetics
Presenilin-2 - genetics
Prevalence
Risk Factors
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Description
Summary:Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals. Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances. Three causative genes have been associated with autosomal dominant familial AD (APP, PSEN1, and PSEN2) and 1 genetic risk factor (APOEε4 allele). Identification of these genes has led to a number of animal models that have been useful to study the pathogenesis underlying AD. In this article, we provide an overview of the clinical and genetic features of AD.
ISSN:0891-9887
DOI:10.1177/0891988710383571