Reversible pH Lability of Crosslinked Vault Nanocapsules

Vaults are ubiquitous, self-assembled protein nanocapsules with dimension in the sub- 100 nm range that are conserved across diverse phyla from worms to humans. Their normal presence in humans at a copy number of over 10,000/cell makes them attractive as potential drug delivery vehicles. Toward this...

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Bibliographic Details
Published in:Nano letters 2008-09, Vol.8 (10), p.3510-3515
Main Authors: Yu, Marcella, Ng, Benny C., Rome, Leonard H., Tolbert, Sarah H., Monbouquette, Harold G.
Format: Article
Language:English
Online Access:Get full text
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Summary:Vaults are ubiquitous, self-assembled protein nanocapsules with dimension in the sub- 100 nm range that are conserved across diverse phyla from worms to humans. Their normal presence in humans at a copy number of over 10,000/cell makes them attractive as potential drug delivery vehicles. Toward this goal, bifunctional amine-reactive reagents are shown to be useful for the reversible crosslinking of recombinant vaults such that they may be closed and opened in a controllable manner.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl080536z