Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability

The aim of this study was to estimate the prevalence and determinants of vitamin D deficiency in patients with rheumatoid arthritis (RA) as compared to healthy controls and to analyze the association between 25-hydroxyvitamin D (25(OH)D) with disease activity and disability. The study includes 1,191...

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Published in:Arthritis research & therapy 2010-01, Vol.12 (6), p.R216-R216, Article R216
Main Authors: Rossini, Maurizio, Maddali Bongi, Susanna, La Montagna, Giovanni, Minisola, Giovanni, Malavolta, Nazzarena, Bernini, Luigi, Cacace, Enrico, Sinigaglia, Luigi, Di Munno, Ombretta, Adami, Silvano
Format: Article
Language:English
Subjects:
Activities of Daily Living
Arthritis, Rheumatoid - complications
Demographic aspects
Development and progression
Disability Evaluation
Distribution
Female
Humans
Male
Middle Aged
Prevalence
Rheumatoid arthritis
Severity of Illness Index
Vitamin D deficiency
Vitamin D Deficiency - complications
Vitamin D Deficiency - epidemiology
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Summary:The aim of this study was to estimate the prevalence and determinants of vitamin D deficiency in patients with rheumatoid arthritis (RA) as compared to healthy controls and to analyze the association between 25-hydroxyvitamin D (25(OH)D) with disease activity and disability. The study includes 1,191 consecutive RA patients (85% women) and 1,019 controls, not on vitamin D supplements, from 22 Italian rheumatology centres. Together with parameters of disease activity, functional impairment, and mean sun exposure time, all patients had serum 25(OH)D measured in a centralized laboratory. A total of 55% of RA patients were not taking vitamin D supplements; the proportion of these with vitamin D deficiency (25(OH)D level
ISSN:1478-6354
1478-6362
1478-6354
DOI:10.1186/ar3195