Avian Sarcoma Virus 17 Carries the jun Oncogene

Biologically active molecular clones of avian sarcoma virus 17 (ASV 17) contain a replication-defective proviral genome of 3.5 kilobases (kb). The genome retains partial gag and env sequences, which flank a cell-derived putative oncogene of 0.93 kb, termed jun. The jun gene lacks preserved coding do...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1987-05, Vol.84 (9), p.2848-2852
Main Authors: Maki, Yoshio, Bos, Timothy J., Davis, Christie, Starbuck, Michael, Vogt, Peter K.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Avian sarcoma viruses
Avian Sarcoma Viruses - genetics
Bacteriophages
Base Sequence
Biological and medical sciences
Cell Transformation, Neoplastic
Cells, Cultured
Chick Embryo
Chickens
DNA
DNA probes
DNA Restriction Enzymes
Fundamental and applied biological sciences. Psychology
Genes, Viral
Genetics
Genomes
Helper viruses
Microbiology
Nucleic Acid Hybridization
Oncogene Proteins, Viral - genetics
Oncogenes
Retroviridae
Transfection
Virology
Viruses
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Description
Summary:Biologically active molecular clones of avian sarcoma virus 17 (ASV 17) contain a replication-defective proviral genome of 3.5 kilobases (kb). The genome retains partial gag and env sequences, which flank a cell-derived putative oncogene of 0.93 kb, termed jun. The jun gene lacks preserved coding domains of tyrosine-specific protein kinases. It also shows no significant nucleic acid homology with other known oncogenes. The probable transformation-specific protein in ASV 17-transformed cells is a 55-kDa gag-jun fusion product.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.84.9.2848