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Infrared spectroscopy with multivariate analysis to interrogate endometrial tissue: a novel and objective diagnostic approach
Background: Endometrial cancer is the most common gynaecological malignancy in the United Kingdom. Diagnosis currently involves subjective expert interpretation of highly processed tissue, primarily using microscopy. Previous work has shown that infrared (IR) spectroscopy can be used to distinguish...
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| Published in: | British journal of cancer 2011-03, Vol.104 (5), p.790-797 |
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| container_end_page | 797 |
| container_issue | 5 |
| container_start_page | 790 |
| container_title | British journal of cancer |
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| creator | Taylor, S E Cheung, K T Patel, I I Trevisan, J Stringfellow, H F Ashton, K M Wood, N J Keating, P J Martin-Hirsch, P L Martin, F L |
| description | Background:
Endometrial cancer is the most common gynaecological malignancy in the United Kingdom. Diagnosis currently involves subjective expert interpretation of highly processed tissue, primarily using microscopy. Previous work has shown that infrared (IR) spectroscopy can be used to distinguish between benign and malignant cells in a variety of tissue types.
Methods:
Tissue was obtained from 76 patients undergoing hysterectomy, 36 had endometrial cancer. Slivers of endometrial tissue (tumour and tumour-adjacent tissue if present) were dissected and placed in fixative solution. Before analysis, tissues were thinly sliced, washed, mounted on low-E slides and desiccated; 10 IR spectra were obtained per slice by attenuated total reflection Fourier-transform IR (ATR-FTIR) spectroscopy. Derived data was subjected to principal component analysis followed by linear discriminant analysis. Post-spectroscopy analyses, tissue sections were haematoxylin and eosin-stained to provide histological verification.
Results:
Using this approach, it is possible to distinguish benign from malignant endometrial tissue, and various subtypes of both. Cluster vector plots of benign (verified post-spectroscopy to be free of identifiable pathology)
vs
malignant tissue indicate the importance of the lipid and secondary protein structure (Amide I and Amide II) regions of the spectrum.
Conclusion:
These findings point towards the possibility of a simple objective test for endometrial cancer using ATR-FTIR spectroscopy. This would facilitate earlier diagnosis and so reduce the morbidity and mortality associated with this disease. |
| doi_str_mv | 10.1038/sj.bjc.6606094 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3048205</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>855206242</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-9a4094e2c08af90e005590cfc2d37ac678e095878e18334e686acc966ee6af953</originalsourceid><addsrcrecordid>eNp1kc2P0zAQxSMEYsvClRvIQkKc2p04sePsAQmt-FhpJS5wtqbOtHWU2sF2inrgf8dVu11A4mTZ83vPM_OK4mUJixIqdRX7xbI3CylBQls_KmalqPi8VLx5XMwAoJlDy-GieBZjn68tqOZpccHLikteNbPi161bBQzUsTiSScFH48c9-2nThm2nIdkdBouJGDoc9tFGljyzLlEIfn14J9f5LaUMDSzZGCe6Zsic39GQNR3zyz772h2xzuLa-ZisYTiOwaPZPC-erHCI9OJ0XhbfP338dvNlfvf18-3Nh7u5EaDSvMU6D0fcgMJVCwQgRAtmZXhXNWhkowhaofJRqqqqSSqJxrRSEsksENVl8f7oO07LLXWGXAo46DHYLYa99mj13xVnN3rtd7qCWnE4GLw7GQT_Y6KY9NZGQ8OAjvwUtRKCg-Q1z-Sbf8jeTyEv7wDVdSlEVWdocYRMXngMtDq3UoI-5Kpjr3Ou-pRrFrz-c4Azfh9kBt6eAIwGh5ypMzY-cHUJjRAH7urIxVxyawoP7f3361dHhcM0BTpb3td_A6SCyTQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>854415534</pqid></control><display><type>article</type><title>Infrared spectroscopy with multivariate analysis to interrogate endometrial tissue: a novel and objective diagnostic approach</title><source>PubMed Central Free</source><creator>Taylor, S E ; Cheung, K T ; Patel, I I ; Trevisan, J ; Stringfellow, H F ; Ashton, K M ; Wood, N J ; Keating, P J ; Martin-Hirsch, P L ; Martin, F L</creator><creatorcontrib>Taylor, S E ; Cheung, K T ; Patel, I I ; Trevisan, J ; Stringfellow, H F ; Ashton, K M ; Wood, N J ; Keating, P J ; Martin-Hirsch, P L ; Martin, F L</creatorcontrib><description>Background:
Endometrial cancer is the most common gynaecological malignancy in the United Kingdom. Diagnosis currently involves subjective expert interpretation of highly processed tissue, primarily using microscopy. Previous work has shown that infrared (IR) spectroscopy can be used to distinguish between benign and malignant cells in a variety of tissue types.
Methods:
Tissue was obtained from 76 patients undergoing hysterectomy, 36 had endometrial cancer. Slivers of endometrial tissue (tumour and tumour-adjacent tissue if present) were dissected and placed in fixative solution. Before analysis, tissues were thinly sliced, washed, mounted on low-E slides and desiccated; 10 IR spectra were obtained per slice by attenuated total reflection Fourier-transform IR (ATR-FTIR) spectroscopy. Derived data was subjected to principal component analysis followed by linear discriminant analysis. Post-spectroscopy analyses, tissue sections were haematoxylin and eosin-stained to provide histological verification.
Results:
Using this approach, it is possible to distinguish benign from malignant endometrial tissue, and various subtypes of both. Cluster vector plots of benign (verified post-spectroscopy to be free of identifiable pathology)
vs
malignant tissue indicate the importance of the lipid and secondary protein structure (Amide I and Amide II) regions of the spectrum.
Conclusion:
These findings point towards the possibility of a simple objective test for endometrial cancer using ATR-FTIR spectroscopy. This would facilitate earlier diagnosis and so reduce the morbidity and mortality associated with this disease.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6606094</identifier><identifier>PMID: 21326237</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/1647/527/2257 ; 692/699/67/1517/1931 ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Drug Resistance ; Endometrial Neoplasms - diagnosis ; Endometrium - pathology ; Epidemiology ; Female ; Genital system. Mammary gland ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Molecular Diagnostics ; Molecular Medicine ; Multivariate Analysis ; Oncology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Spectroscopy, Fourier Transform Infrared - methods ; Tumors</subject><ispartof>British journal of cancer, 2011-03, Vol.104 (5), p.790-797</ispartof><rights>The Author(s) 2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Mar 1, 2011</rights><rights>Copyright © 2011 Cancer Research UK 2011 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-9a4094e2c08af90e005590cfc2d37ac678e095878e18334e686acc966ee6af953</citedby><cites>FETCH-LOGICAL-c508t-9a4094e2c08af90e005590cfc2d37ac678e095878e18334e686acc966ee6af953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048205/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048205/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24107557$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21326237$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taylor, S E</creatorcontrib><creatorcontrib>Cheung, K T</creatorcontrib><creatorcontrib>Patel, I I</creatorcontrib><creatorcontrib>Trevisan, J</creatorcontrib><creatorcontrib>Stringfellow, H F</creatorcontrib><creatorcontrib>Ashton, K M</creatorcontrib><creatorcontrib>Wood, N J</creatorcontrib><creatorcontrib>Keating, P J</creatorcontrib><creatorcontrib>Martin-Hirsch, P L</creatorcontrib><creatorcontrib>Martin, F L</creatorcontrib><title>Infrared spectroscopy with multivariate analysis to interrogate endometrial tissue: a novel and objective diagnostic approach</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Endometrial cancer is the most common gynaecological malignancy in the United Kingdom. Diagnosis currently involves subjective expert interpretation of highly processed tissue, primarily using microscopy. Previous work has shown that infrared (IR) spectroscopy can be used to distinguish between benign and malignant cells in a variety of tissue types.
Methods:
Tissue was obtained from 76 patients undergoing hysterectomy, 36 had endometrial cancer. Slivers of endometrial tissue (tumour and tumour-adjacent tissue if present) were dissected and placed in fixative solution. Before analysis, tissues were thinly sliced, washed, mounted on low-E slides and desiccated; 10 IR spectra were obtained per slice by attenuated total reflection Fourier-transform IR (ATR-FTIR) spectroscopy. Derived data was subjected to principal component analysis followed by linear discriminant analysis. Post-spectroscopy analyses, tissue sections were haematoxylin and eosin-stained to provide histological verification.
Results:
Using this approach, it is possible to distinguish benign from malignant endometrial tissue, and various subtypes of both. Cluster vector plots of benign (verified post-spectroscopy to be free of identifiable pathology)
vs
malignant tissue indicate the importance of the lipid and secondary protein structure (Amide I and Amide II) regions of the spectrum.
Conclusion:
These findings point towards the possibility of a simple objective test for endometrial cancer using ATR-FTIR spectroscopy. This would facilitate earlier diagnosis and so reduce the morbidity and mortality associated with this disease.</description><subject>631/1647/527/2257</subject><subject>692/699/67/1517/1931</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Drug Resistance</subject><subject>Endometrial Neoplasms - diagnosis</subject><subject>Endometrium - pathology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genital system. Mammary gland</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Molecular Diagnostics</subject><subject>Molecular Medicine</subject><subject>Multivariate Analysis</subject><subject>Oncology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Spectroscopy, Fourier Transform Infrared - methods</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kc2P0zAQxSMEYsvClRvIQkKc2p04sePsAQmt-FhpJS5wtqbOtHWU2sF2inrgf8dVu11A4mTZ83vPM_OK4mUJixIqdRX7xbI3CylBQls_KmalqPi8VLx5XMwAoJlDy-GieBZjn68tqOZpccHLikteNbPi161bBQzUsTiSScFH48c9-2nThm2nIdkdBouJGDoc9tFGljyzLlEIfn14J9f5LaUMDSzZGCe6Zsic39GQNR3zyz772h2xzuLa-ZisYTiOwaPZPC-erHCI9OJ0XhbfP338dvNlfvf18-3Nh7u5EaDSvMU6D0fcgMJVCwQgRAtmZXhXNWhkowhaofJRqqqqSSqJxrRSEsksENVl8f7oO07LLXWGXAo46DHYLYa99mj13xVnN3rtd7qCWnE4GLw7GQT_Y6KY9NZGQ8OAjvwUtRKCg-Q1z-Sbf8jeTyEv7wDVdSlEVWdocYRMXngMtDq3UoI-5Kpjr3Ou-pRrFrz-c4Azfh9kBt6eAIwGh5ypMzY-cHUJjRAH7urIxVxyawoP7f3361dHhcM0BTpb3td_A6SCyTQ</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Taylor, S E</creator><creator>Cheung, K T</creator><creator>Patel, I I</creator><creator>Trevisan, J</creator><creator>Stringfellow, H F</creator><creator>Ashton, K M</creator><creator>Wood, N J</creator><creator>Keating, P J</creator><creator>Martin-Hirsch, P L</creator><creator>Martin, F L</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110301</creationdate><title>Infrared spectroscopy with multivariate analysis to interrogate endometrial tissue: a novel and objective diagnostic approach</title><author>Taylor, S E ; Cheung, K T ; Patel, I I ; Trevisan, J ; Stringfellow, H F ; Ashton, K M ; Wood, N J ; Keating, P J ; Martin-Hirsch, P L ; Martin, F L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-9a4094e2c08af90e005590cfc2d37ac678e095878e18334e686acc966ee6af953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>631/1647/527/2257</topic><topic>692/699/67/1517/1931</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Drug Resistance</topic><topic>Endometrial Neoplasms - diagnosis</topic><topic>Endometrium - pathology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Genital system. Mammary gland</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Molecular Diagnostics</topic><topic>Molecular Medicine</topic><topic>Multivariate Analysis</topic><topic>Oncology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Spectroscopy, Fourier Transform Infrared - methods</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taylor, S E</creatorcontrib><creatorcontrib>Cheung, K T</creatorcontrib><creatorcontrib>Patel, I I</creatorcontrib><creatorcontrib>Trevisan, J</creatorcontrib><creatorcontrib>Stringfellow, H F</creatorcontrib><creatorcontrib>Ashton, K M</creatorcontrib><creatorcontrib>Wood, N J</creatorcontrib><creatorcontrib>Keating, P J</creatorcontrib><creatorcontrib>Martin-Hirsch, P L</creatorcontrib><creatorcontrib>Martin, F L</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taylor, S E</au><au>Cheung, K T</au><au>Patel, I I</au><au>Trevisan, J</au><au>Stringfellow, H F</au><au>Ashton, K M</au><au>Wood, N J</au><au>Keating, P J</au><au>Martin-Hirsch, P L</au><au>Martin, F L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infrared spectroscopy with multivariate analysis to interrogate endometrial tissue: a novel and objective diagnostic approach</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>104</volume><issue>5</issue><spage>790</spage><epage>797</epage><pages>790-797</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Endometrial cancer is the most common gynaecological malignancy in the United Kingdom. Diagnosis currently involves subjective expert interpretation of highly processed tissue, primarily using microscopy. Previous work has shown that infrared (IR) spectroscopy can be used to distinguish between benign and malignant cells in a variety of tissue types.
Methods:
Tissue was obtained from 76 patients undergoing hysterectomy, 36 had endometrial cancer. Slivers of endometrial tissue (tumour and tumour-adjacent tissue if present) were dissected and placed in fixative solution. Before analysis, tissues were thinly sliced, washed, mounted on low-E slides and desiccated; 10 IR spectra were obtained per slice by attenuated total reflection Fourier-transform IR (ATR-FTIR) spectroscopy. Derived data was subjected to principal component analysis followed by linear discriminant analysis. Post-spectroscopy analyses, tissue sections were haematoxylin and eosin-stained to provide histological verification.
Results:
Using this approach, it is possible to distinguish benign from malignant endometrial tissue, and various subtypes of both. Cluster vector plots of benign (verified post-spectroscopy to be free of identifiable pathology)
vs
malignant tissue indicate the importance of the lipid and secondary protein structure (Amide I and Amide II) regions of the spectrum.
Conclusion:
These findings point towards the possibility of a simple objective test for endometrial cancer using ATR-FTIR spectroscopy. This would facilitate earlier diagnosis and so reduce the morbidity and mortality associated with this disease.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21326237</pmid><doi>10.1038/sj.bjc.6606094</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/1647/527/2257 692/699/67/1517/1931 Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Drug Resistance Endometrial Neoplasms - diagnosis Endometrium - pathology Epidemiology Female Genital system. Mammary gland Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Molecular Diagnostics Molecular Medicine Multivariate Analysis Oncology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Spectroscopy, Fourier Transform Infrared - methods Tumors |
| title | Infrared spectroscopy with multivariate analysis to interrogate endometrial tissue: a novel and objective diagnostic approach |
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