Fibroblast growth factor signaling in the developing neuroendocrine hypothalamus

Research Highlights ► FGF signaling is most critical during the fate specification of GnRH neurons. ► FGF signaling maintains the postnatal GnRH system. ► Deficiency in FGF8 signaling deleteriously impacts the neuroendocrine hypothalamus.

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Bibliographic Details
Published in:Frontiers in neuroendocrinology 2011-01, Vol.32 (1), p.95-107
Main Authors: Tsai, Pei-San, Brooks, Leah R, Rochester, Johanna R, Kavanaugh, Scott I, Chung, Wilson C.J
Format: Article
Language:English
Subjects:
Animals
Diencephalon
Endocrinology & Metabolism
FGF signaling
Fibroblast Growth Factors - genetics
Fibroblast Growth Factors - metabolism
Fibroblast Growth Factors - physiology
Gene Expression Regulation, Developmental
GnRH neurons
Humans
Hypothalamic nuclei
Hypothalamus - embryology
Hypothalamus - metabolism
Models, Biological
Neurosecretory Systems - embryology
Neurosecretory Systems - metabolism
Olfactory placode
Oxytocin
Receptors, Fibroblast Growth Factor - genetics
Receptors, Fibroblast Growth Factor - metabolism
Receptors, Fibroblast Growth Factor - physiology
Signal Transduction - genetics
Signal Transduction - physiology
Vasopressin
Ventricular zone
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Description
Summary:Research Highlights ► FGF signaling is most critical during the fate specification of GnRH neurons. ► FGF signaling maintains the postnatal GnRH system. ► Deficiency in FGF8 signaling deleteriously impacts the neuroendocrine hypothalamus.
ISSN:0091-3022
1095-6808
DOI:10.1016/j.yfrne.2010.11.002