Plasminogen and Its Receptors as Regulators of Cardiovascular Inflammatory Responses

In addition to its role in fibrinolysis, plasminogen (Plg) influences inflammatory cell migration and thereby plays a prominent role in cardiovascular pathology. The contribution of Plg to inflammatory cell recruitment depends on its tethering to the surface of responding cells. Plasminogen receptor...

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Bibliographic Details
Published in:Trends in cardiovascular medicine 2010-05, Vol.20 (4), p.120-124
Main Authors: Das, Riku, Pluskota, Elzbieta, Plow, Edward F
Format: Article
Language:English
Subjects:
Binding sites
Calcium Channels
Cardiovascular
Cell adhesion & migration
Fibrinolysin
Heart Diseases - pathology
Heart Diseases - prevention & control
Humans
Inflammation - pathology
Integrins
Leukocytes - physiology
Ligands
Plasminogen
Proteins
Recruitment
Rodents
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Summary:In addition to its role in fibrinolysis, plasminogen (Plg) influences inflammatory cell migration and thereby plays a prominent role in cardiovascular pathology. The contribution of Plg to inflammatory cell recruitment depends on its tethering to the surface of responding cells. Plasminogen receptors (Plg-Rs) are heterogeneous and can be classified as tailless, lacking cytoplasmic tails, or tailed (having cytoplasmic tails). In vivo observations implicate several tailless Plg-Rs in inflammatory responses. Tailed Plg-Rs on leukocytes include several integrins, which have also been implicated in Plg-dependent responses. Surface expression of both tailless and tailed Plg-Rs can be modulated in number and/or function. A common mechanism involving intracellular calcium mobilization and calcium channels regulates expression of both classes of Plg-Rs. Data are emerging to indicate that targeting Plg and Plg-Rs may limit inflammation and cardiovascular pathology.
ISSN:1050-1738
1873-2615
DOI:10.1016/j.tcm.2010.10.002