A case of Goodpasture's syndrome with massive pulmonary hemorrhage

We present a typical case of Goodpasture's syndrome with massive pulmonary hemorrhage and acute deterioration of renal function. A 20-year-old male was admitted due to severe azotemia (blood urea nitrogen 214.7 mg/dL, serum creatinine 30.2 mg/dL) and was treated with emergency hemodialysis. On...

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Bibliographic Details
Published in:Journal of Korean medical science 2000-02, Vol.15 (1), p.99-102
Main Authors: Kim, Y O, Choi, J Y, Park, J I, Yoon, S A, Yang, C W, Hyoung, K, Bang, B K
Format: Article
Language:English
Subjects:
Adult
Anti-Glomerular Basement Membrane Disease - complications
Anti-Glomerular Basement Membrane Disease - physiopathology
Hemoptysis - etiology
Humans
Kidney - physiopathology
Male
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Summary:We present a typical case of Goodpasture's syndrome with massive pulmonary hemorrhage and acute deterioration of renal function. A 20-year-old male was admitted due to severe azotemia (blood urea nitrogen 214.7 mg/dL, serum creatinine 30.2 mg/dL) and was treated with emergency hemodialysis. On the 4th hospital day, a sudden onset of pulmonary hemorrhage developed. The circulating level of anti-glomerular basement membrane antibody was then elevated highly, and the kidney biopsy showed crescentic glomerulonephritis and linear deposition of IgG along the glomerular capillary. The patient was treated with intravenous high dose-steroid, oral cyclophosphamide and plasma exchanges. The pulmonary hemorrhage improved with the therapy, however, his renal function did not improve. He is currently on a regular schedule of hemodialysis.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2000.15.1.99