The effect of oxytocin antagonist on uterus in response to exogenous oxytocin

This study was performed to determine the action mode of oxytocin antagonist. In Study 1, the duration of in vivo action of oxytocin antagonist I (AI) was examined. After infusing AI, oxytocin was given and repeated every hour for 5 hr. Uterine activities were monitored with a polygraph. Study 2 det...

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Bibliographic Details
Published in:Journal of Korean medical science 2000-06, Vol.15 (3), p.299-302
Main Authors: Park, S H, Song, C H, Pak, S C, Flouret, G, Wilson, Jr, L
Format: Article
Language:English
Subjects:
Animals
Female
Oxytocin - antagonists & inhibitors
Oxytocin - metabolism
Oxytocin - pharmacology
Rats
Receptors, Oxytocin - metabolism
Uterus - drug effects
Uterus - physiology
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Summary:This study was performed to determine the action mode of oxytocin antagonist. In Study 1, the duration of in vivo action of oxytocin antagonist I (AI) was examined. After infusing AI, oxytocin was given and repeated every hour for 5 hr. Uterine activities were monitored with a polygraph. Study 2 determined the effect of AI on uterine oxytocin receptor number (Rn) and binding affinity (Kd). AI treated rats were sacrificed at 0.5 and 4 hr later for receptor assay. In Study 1, the uterine contractile response to oxytocin was significantly inhibited (p0.05) at later hours. In Study 2, no differences (p>0.05) between the AI and control animals in either oxytocin receptor number or binding affinity was found. These data suggest that the major mode of AI action is via competitive inhibition at the uterine oxytocin receptor and not by altering receptor number or binding affinity. AI is suggested to have the potential of being a potent and specific tocolytic agent for prevention of preterm labor in human.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2000.15.3.299