Effects of oncostatin M on hormone release of rat pituitary cells in primary culture

It has become increasingly clear that cytokines play an important role in modulating neuroendocrine regulation, especially in the secretion of corticotropin (ACTH) in the pituitary. Oncostatin M (OSM), a cytokine of IL-6 family has been reported to increase ACTH secretion and pro-opiomelanocortin (P...

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Bibliographic Details
Published in:Journal of Korean medical science 2000-06, Vol.15 (3), p.323-326
Main Authors: Kim, D S, Choi, H S, Park, Y S, Kim, T W
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - secretion
Animals
Cells, Cultured
Cytokines - metabolism
Cytokines - pharmacology
Growth Hormone - secretion
Inflammation Mediators - metabolism
Inflammation Mediators - pharmacology
Male
Oncostatin M
Peptides - metabolism
Peptides - pharmacology
Pituitary Gland - cytology
Pituitary Gland - drug effects
Pituitary Gland - metabolism
Prolactin - secretion
Rats
Rats, Inbred WF
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Summary:It has become increasingly clear that cytokines play an important role in modulating neuroendocrine regulation, especially in the secretion of corticotropin (ACTH) in the pituitary. Oncostatin M (OSM), a cytokine of IL-6 family has been reported to increase ACTH secretion and pro-opiomelanocortin (POMC) transcription in murine corticotroph pituitary tumor cells (AtT20 cells). The present study was undertaken to determine the effects of OSM on hormonal release in primary culture of rat pituitary cells. Growth hormone or prolactin release was not affected by OSM. OSM (1 nM) stimulated ACTH release (35.1% increase versus control, p
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2000.15.3.323