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Apolipoprotein E genotype in Korean schizophrenic patients

The apolipoprotein E (APOE) epsilon4 allele is a known risk factor for the development of Alzheimer's disease, however, an association of the APOE genotype with schizophrenia is controversial. We investigated the association in 60 Korean schizophrenic patients and 60 healthy controls. APOE geno...

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Published in:	Journal of Korean medical science 2001-12, Vol.16 (6), p.781-783
Main Authors:	Lee, M K, Park, A J, Nam, B Y, Min, K J, Kee, B S, Park, D B
Format:	Article
Language:	English
Subjects:	Adult Age Distribution Apolipoprotein E2 Apolipoprotein E3 Apolipoprotein E4 Apolipoproteins E - genetics Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Korea Male Risk Factors Schizophrenia - epidemiology Schizophrenia - genetics Sex Distribution
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container_title	Journal of Korean medical science
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creator	Lee, M K Park, A J Nam, B Y Min, K J Kee, B S Park, D B
description	The apolipoprotein E (APOE) epsilon4 allele is a known risk factor for the development of Alzheimer's disease, however, an association of the APOE genotype with schizophrenia is controversial. We investigated the association in 60 Korean schizophrenic patients and 60 healthy controls. APOE genotypes were identified by reverse hybridization-based line probe assay. There were significant differences in the distribution of APOE genotypes between schizophrenic patients and controls. APOE epsilon2 and epsilon3 allele frequencies in schizophrenic patients were significantly different from those in controls. Our results suggest that APOE alleles seem to be operative in the pathogenesis of schizophrenic disorders.
doi_str_mv	10.3346/jkms.2001.16.6.781
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Our results suggest that APOE alleles seem to be operative in the pathogenesis of schizophrenic disorders.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Apolipoprotein E2</subject><subject>Apolipoprotein E3</subject><subject>Apolipoprotein E4</subject><subject>Apolipoproteins E - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Korea</subject><subject>Male</subject><subject>Risk Factors</subject><subject>Schizophrenia - epidemiology</subject><subject>Schizophrenia - genetics</subject><subject>Sex Distribution</subject><issn>1011-8934</issn><issn>1598-6357</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNpVkMtLxDAQxoMorq9_wIP05K01jzZJPQgi6wMFL3oOaTpxs7ZNTLqC_vV2cfFxmhnmm-8bfggdE1wwVvKz5WufCooxKQgveCEk2UJ7pKplzlkltqceE5LLmpUztJ_SEmNaVZTtohkhopSM0z10fhl854IP0Y_ghmyevcDgx48A2TTd-wh6yJJZuE8fFhEGZ7KgRwfDmA7RjtVdgqNNPUDP1_Onq9v84fHm7uryITeslmNONakYaMK5tJSTqgRjTVNSazRuq5rhRkoL1ojSNmCANQK3rS6xaLUVNbHsAF18-4ZV00NrpuyoOxWi63X8UF479X8zuIV68e-K4aqUGE8GpxuD6N9WkEbVu2Sg6_QAfpWUoIwzIvgkpN9CE31KEexPCMFqjVytkas1ckW44mpCPh2d_H3v92TDmH0B7QeAnQ</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Lee, M K</creator><creator>Park, A J</creator><creator>Nam, B Y</creator><creator>Min, K J</creator><creator>Kee, B S</creator><creator>Park, D B</creator><general>Korean Academy of Medical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20011201</creationdate><title>Apolipoprotein E genotype in Korean schizophrenic patients</title><author>Lee, M K ; Park, A J ; Nam, B Y ; Min, K J ; Kee, B S ; Park, D B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-2a153ea1668f26154ecfcb42fca0d5930b88fefc74fbece3b70dda407daf791f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Apolipoprotein E2</topic><topic>Apolipoprotein E3</topic><topic>Apolipoprotein E4</topic><topic>Apolipoproteins E - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Korea</topic><topic>Male</topic><topic>Risk Factors</topic><topic>Schizophrenia - epidemiology</topic><topic>Schizophrenia - genetics</topic><topic>Sex Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, M K</creatorcontrib><creatorcontrib>Park, A J</creatorcontrib><creatorcontrib>Nam, B Y</creatorcontrib><creatorcontrib>Min, K J</creatorcontrib><creatorcontrib>Kee, B S</creatorcontrib><creatorcontrib>Park, D B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Korean medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, M K</au><au>Park, A J</au><au>Nam, B Y</au><au>Min, K J</au><au>Kee, B S</au><au>Park, D B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apolipoprotein E genotype in Korean schizophrenic patients</atitle><jtitle>Journal of Korean medical science</jtitle><addtitle>J Korean Med Sci</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>16</volume><issue>6</issue><spage>781</spage><epage>783</epage><pages>781-783</pages><issn>1011-8934</issn><eissn>1598-6357</eissn><abstract>The apolipoprotein E (APOE) epsilon4 allele is a known risk factor for the development of Alzheimer's disease, however, an association of the APOE genotype with schizophrenia is controversial. 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subjects	Adult Age Distribution Apolipoprotein E2 Apolipoprotein E3 Apolipoprotein E4 Apolipoproteins E - genetics Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Korea Male Risk Factors Schizophrenia - epidemiology Schizophrenia - genetics Sex Distribution
title	Apolipoprotein E genotype in Korean schizophrenic patients
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