Expression of cyclin B1 and cdc2 in nodal non-Hodgkin's lymphoma and its prognostic implications

To investigate the role of cyclin B1 and cdc2 in the pathogenesis and progression of malignant lymphoma, 68 cases of nodal non-Hodgkin's lymphoma were examined about the expression of cyclin B1 and cdc2 along with p53 and Ki-67 by immunohistochemical method. The correlation of their expression...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Korean medical science 2002-06, Vol.17 (3), p.322-327
Main Authors: Jin, Yun Hee, Park, Chan Kum
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
CDC2 Protein Kinase - biosynthesis
Child
Child, Preschool
Cyclin B - biosynthesis
Cyclin B1
Female
Humans
Immunohistochemistry
Ki-67 Antigen - biosynthesis
Lymph Nodes - metabolism
Lymph Nodes - pathology
Lymphoma, Non-Hodgkin - metabolism
Lymphoma, Non-Hodgkin - mortality
Lymphoma, Non-Hodgkin - pathology
Male
Middle Aged
Palatine Tonsil - metabolism
Palatine Tonsil - pathology
Predictive Value of Tests
Prognosis
Survival Analysis
Tumor Suppressor Protein p53 - biosynthesis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate the role of cyclin B1 and cdc2 in the pathogenesis and progression of malignant lymphoma, 68 cases of nodal non-Hodgkin's lymphoma were examined about the expression of cyclin B1 and cdc2 along with p53 and Ki-67 by immunohistochemical method. The correlation of their expression with various clinicopathologic findings was also analyzed. Cyclin B1 and cdc2 were diffusely expressed in 39 cases (57.4%) and 54 cases (79.4%) out of 68 cases studied, respectively. The mean labeling indices of cyclin B1 and cdc2 in malignant lymphoma were 31.9% and 68.0%, respectively. In normal lymphoid tissues, cyclin B1 and cdc2 were expressed predominantly in the germinal center with mean labeling indices of 13.9% and 28.3%, respectively. The correlation between the expression of cyclin B1 and cdc2 was noted (p=0.013). The expression of Ki-67 was correlated with that of cyclin B1 (p=0.023) and marginally correlated with that of cdc2 (p=0.056). The expression of cdc2 and p53 in complete remission group to chemotherapy was lower than that of progressive disease group (p=0.047, p=0.049). In multivariate analysis, the clinical stage alone showed significance on overall survival (p=0.049). In conclusion, cyclin B1 and cdc2 appeared to be involved in the genesis or progression of malignant lymphoma and cdc2 can be a useful marker for response to chemotherapy.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2002.17.3.322