Differential expression of hypoxia inducible factor-1 alpha and tumor cell proliferation between squamous cell carcinomas and adenocarcinomas among operable non-small cell lung carcinomas

This study aimed to evaluate whether the elevated level of hypoxia-inducible factor-1alpha (HIF-1alpha) correlated with histologic types, angiogenesis, tumor cell proliferation, and clinical parameters in common non-small cell lung carcinomas (NSCLCs). We performed immunohistochemical stains using p...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Korean medical science 2003-04, Vol.18 (2), p.196-203
Main Authors: Lee, Chang Hun, Lee, Min Ki, Kang, Chi Duk, Kim, Young Dae, Park, Do Youn, Kim, Jee Yeon, Sol, Mee Young, Suh, Kang Suek
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Animals
Antigens, CD34 - metabolism
Carcinoma, Non-Small-Cell Lung - metabolism
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - surgery
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cell Division - physiology
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
Immunohistochemistry
Lung Neoplasms
Proliferating Cell Nuclear Antigen - metabolism
Survival Rate
Transcription Factors - metabolism
Vascular Endothelial Growth Factor A - metabolism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed to evaluate whether the elevated level of hypoxia-inducible factor-1alpha (HIF-1alpha) correlated with histologic types, angiogenesis, tumor cell proliferation, and clinical parameters in common non-small cell lung carcinomas (NSCLCs). We performed immunohistochemical stains using paraffin-embedded tissue blocks from 84 cases of operable NSCLC [No. of squamous cell carcinoma (SCC), 45; No. of adenocarcinoma (AC), 39]. HIF-1alpha expression was related with histologic types (66.7% in SCCs vs 20.5% in ACs, p0.05, respectively). As for the histologic types, MVD and PCNA index were significantly higher in SCCs than in ACs (p=0.009 and p=0.016, respectively). Among HIF-1alpha positive carcinomas, MVD was significantly higher in HIF-1alpha positive SCCs than in HIF-1alpha positive ACs (p=0.023). The overall survival curves were not associated with HIF-1alpha expression or any other histologic parameters (p>0.05). These findings suggest that HIF-1alpha expression in NSCLCs may play a differential role according to histologic types, but its prognostic significance is indeterminate.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2003.18.2.196