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Multifocal inflammatory leukoencephalopathy: use of thallium-201 SPECT and proton MRS
In a patient receiving 5-fluorouracil and levamisole, neurologic deficits suggest the cerebral demyelinating syndrome as a differential diagnosis. The authors report a patient diagnosed as multifocal inflammatory leukoencephalopathy for which thallium-201 (201Tl) single photon emission computed tomo...
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| Published in: | Journal of Korean medical science 2003-08, Vol.18 (4), p.621-624 |
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| Language: | English |
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| container_end_page | 624 |
| container_issue | 4 |
| container_start_page | 621 |
| container_title | Journal of Korean medical science |
| container_volume | 18 |
| creator | Hwang, Yang Ha Suh, Chung Kyu Park, Sung Pa |
| description | In a patient receiving 5-fluorouracil and levamisole, neurologic deficits suggest the cerebral demyelinating syndrome as a differential diagnosis. The authors report a patient diagnosed as multifocal inflammatory leukoencephalopathy for which thallium-201 (201Tl) single photon emission computed tomography (SPECT) and proton magnetic resonance spectroscopy (MRS) were employed as noninvasive diagnostic tools. 201Tl SPECT study was negative and proton MRS showed an increase of choline and lactate and well preserved N-acetylaspartate. These findings support histopathologic findings of multifocal inflammatory leukoencephalopathy revealing demyelination with relative axonal sparing in the patient. |
| doi_str_mv | 10.3346/jkms.2003.18.4.621 |
| format | article |
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The authors report a patient diagnosed as multifocal inflammatory leukoencephalopathy for which thallium-201 (201Tl) single photon emission computed tomography (SPECT) and proton magnetic resonance spectroscopy (MRS) were employed as noninvasive diagnostic tools. 201Tl SPECT study was negative and proton MRS showed an increase of choline and lactate and well preserved N-acetylaspartate. 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The authors report a patient diagnosed as multifocal inflammatory leukoencephalopathy for which thallium-201 (201Tl) single photon emission computed tomography (SPECT) and proton magnetic resonance spectroscopy (MRS) were employed as noninvasive diagnostic tools. 201Tl SPECT study was negative and proton MRS showed an increase of choline and lactate and well preserved N-acetylaspartate. These findings support histopathologic findings of multifocal inflammatory leukoencephalopathy revealing demyelination with relative axonal sparing in the patient.</description><subject>Adjuvants, Immunologic - adverse effects</subject><subject>Adjuvants, Immunologic - therapeutic use</subject><subject>Antimetabolites, Antineoplastic - adverse effects</subject><subject>Antimetabolites, Antineoplastic - therapeutic use</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Axons - pathology</subject><subject>Biopsy</subject><subject>Brain - pathology</subject><subject>Brain Neoplasms - secondary</subject><subject>Choline - metabolism</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Diagnosis, Differential</subject><subject>Fluorouracil - adverse effects</subject><subject>Fluorouracil - therapeutic use</subject><subject>Humans</subject><subject>Lactic Acid - metabolism</subject><subject>Leukoencephalopathy, Progressive Multifocal - diagnosis</subject><subject>Leukoencephalopathy, Progressive Multifocal - etiology</subject><subject>Levamisole - adverse effects</subject><subject>Levamisole - therapeutic use</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Thallium Radioisotopes</subject><subject>Tomography, Emission-Computed, Single-Photon - methods</subject><issn>1011-8934</issn><issn>1598-6357</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNpVkMlKA0EQhhtRjEZfwIP0C8zY--JBkBAXSFBMcm46nR4zSc_0MIuQt3dCgsulqqji_wo-AG4wSill4m6zLZqUIERTrFKWCoJPwAXmWiWCcnnazwjjRGnKBuCyaTYIEc4JPQcDTDTpEeoCLKZdaPMsOhtgXmbBFoVtY72DwXfb6Evnq7UNsbLtencPu8bDmMG2X4W8KxKCMJy9j0dzaMsVrOrYxhJOP2ZX4CyzofHXxz4Ei6fxfPSSTN6eX0ePk8RRrdpEk6XETknLONIOIyo8QSuvlkhQnXmhpKKeaM-880xYLPtKreTCKczQUtIheDhwq25Z-JXzZVvbYKo6L2y9M9Hm5v-lzNfmM34ZijhHUvcAcgC4OjZN7bOfLEZmL9nsJZu9ZIOVYaaX3Idu_379jRyt0m_ZBHoH</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Hwang, Yang Ha</creator><creator>Suh, Chung Kyu</creator><creator>Park, Sung Pa</creator><general>Korean Academy of Medical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20030801</creationdate><title>Multifocal inflammatory leukoencephalopathy: use of thallium-201 SPECT and proton MRS</title><author>Hwang, Yang Ha ; Suh, Chung Kyu ; Park, Sung Pa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-92b71c87a4509c1036e20de8b0639fe68783e29e4ece46a17e463a756c8140b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adjuvants, Immunologic - adverse effects</topic><topic>Adjuvants, Immunologic - therapeutic use</topic><topic>Antimetabolites, Antineoplastic - adverse effects</topic><topic>Antimetabolites, Antineoplastic - therapeutic use</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Axons - pathology</topic><topic>Biopsy</topic><topic>Brain - pathology</topic><topic>Brain Neoplasms - secondary</topic><topic>Choline - metabolism</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Diagnosis, Differential</topic><topic>Fluorouracil - adverse effects</topic><topic>Fluorouracil - therapeutic use</topic><topic>Humans</topic><topic>Lactic Acid - metabolism</topic><topic>Leukoencephalopathy, Progressive Multifocal - diagnosis</topic><topic>Leukoencephalopathy, Progressive Multifocal - etiology</topic><topic>Levamisole - adverse effects</topic><topic>Levamisole - therapeutic use</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Thallium Radioisotopes</topic><topic>Tomography, Emission-Computed, Single-Photon - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, Yang Ha</creatorcontrib><creatorcontrib>Suh, Chung Kyu</creatorcontrib><creatorcontrib>Park, Sung Pa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Korean medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Yang Ha</au><au>Suh, Chung Kyu</au><au>Park, Sung Pa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multifocal inflammatory leukoencephalopathy: use of thallium-201 SPECT and proton MRS</atitle><jtitle>Journal of Korean medical science</jtitle><addtitle>J Korean Med Sci</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>18</volume><issue>4</issue><spage>621</spage><epage>624</epage><pages>621-624</pages><issn>1011-8934</issn><eissn>1598-6357</eissn><abstract>In a patient receiving 5-fluorouracil and levamisole, neurologic deficits suggest the cerebral demyelinating syndrome as a differential diagnosis. The authors report a patient diagnosed as multifocal inflammatory leukoencephalopathy for which thallium-201 (201Tl) single photon emission computed tomography (SPECT) and proton magnetic resonance spectroscopy (MRS) were employed as noninvasive diagnostic tools. 201Tl SPECT study was negative and proton MRS showed an increase of choline and lactate and well preserved N-acetylaspartate. These findings support histopathologic findings of multifocal inflammatory leukoencephalopathy revealing demyelination with relative axonal sparing in the patient.</abstract><cop>Korea (South)</cop><pub>Korean Academy of Medical Sciences</pub><pmid>12923348</pmid><doi>10.3346/jkms.2003.18.4.621</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | Adjuvants, Immunologic - adverse effects Adjuvants, Immunologic - therapeutic use Antimetabolites, Antineoplastic - adverse effects Antimetabolites, Antineoplastic - therapeutic use Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Axons - pathology Biopsy Brain - pathology Brain Neoplasms - secondary Choline - metabolism Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Diagnosis, Differential Fluorouracil - adverse effects Fluorouracil - therapeutic use Humans Lactic Acid - metabolism Leukoencephalopathy, Progressive Multifocal - diagnosis Leukoencephalopathy, Progressive Multifocal - etiology Levamisole - adverse effects Levamisole - therapeutic use Magnetic Resonance Spectroscopy - methods Male Middle Aged Neoplasm Metastasis Thallium Radioisotopes Tomography, Emission-Computed, Single-Photon - methods |
| title | Multifocal inflammatory leukoencephalopathy: use of thallium-201 SPECT and proton MRS |
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