Respiratory fluid mechanics

This article covers several aspects of respiratory fluid mechanics that have been actively investigated by our group over the years. For the most part, the topics involve two-phase flows in the respiratory system with applications to normal and diseased lungs, as well as therapeutic interventions. S...

Full description

Saved in:
Bibliographic Details
Published in:Physics of fluids (1994) 2011-02, Vol.23 (2), p.021301-021301-15
Main Author: Grotberg, James B.
Format: Article
Language:English
Subjects:
Award and Invited Papers
Biological and medical sciences
Biomechanics. Biorheology
Fundamental and applied biological sciences. Psychology
Medical sciences
Pneumology
Respiratory system : syndromes and miscellaneous diseases
Tissues, organs and organisms biophysics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This article covers several aspects of respiratory fluid mechanics that have been actively investigated by our group over the years. For the most part, the topics involve two-phase flows in the respiratory system with applications to normal and diseased lungs, as well as therapeutic interventions. Specifically, the topics include liquid plug flow in airways and at airway bifurcations as it relates to surfactant, drug, gene, or stem cell delivery into the lung; liquid plug rupture and its damaging effects on underlying airway epithelial cells as well as a source of crackling sounds in the lung; airway closure from "capillary-elastic instabilities," as well as nonlinear stabilization from oscillatory core flow which we call the "oscillating butter knife;" liquid film, and surfactant dynamics in an oscillating alveolus and the steady streaming, and surfactant spreading on thin viscous films including our discovery of the Grotberg-Borgas-Gaver shock.
ISSN:1070-6631
1089-7666
DOI:10.1063/1.3517737