Mouse models of retinal ganglion cell death and glaucoma

Once considered too difficult to use for glaucoma studies, mice are now becoming a powerful tool in the research of the molecular and pathological events associated with this disease. Often adapting technologies first developed in rats, ganglion cell death in mice can be induced using acute models a...

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Bibliographic Details
Published in:Experimental eye research 2009-04, Vol.88 (4), p.816-824
Main Authors: McKinnon, Stuart J., Schlamp, Cassandra L., Nickells, Robert W.
Format: Article
Language:English
Subjects:
Acute Disease
Animal models
Animals
Anterior chamber
Cell Death
DBA/2J mouse glaucoma
Disease Models, Animal
experimental glaucoma
Eye
Female
Genetic Predisposition to Disease
Glaucoma
Glaucoma - etiology
Glaucoma - genetics
Glaucoma - pathology
Inbreeding
Male
Mice
Mice, Inbred DBA
Mice, Transgenic
optic nerve disease
Optic Nerve Diseases - genetics
Optic neuropathy
retinal ganglion cell
Retinal ganglion cells
Retinal Ganglion Cells - pathology
Transgenic animals
transgenic mice
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Summary:Once considered too difficult to use for glaucoma studies, mice are now becoming a powerful tool in the research of the molecular and pathological events associated with this disease. Often adapting technologies first developed in rats, ganglion cell death in mice can be induced using acute models and chronic models of experimental glaucoma. Similarly, elevated IOP has been reported in transgenic animals carrying defects in targeted genes. Also, one group of mice, from the DBA/2 line of inbred animals, develops a spontaneous optic neuropathy with many features of human glaucoma that is associated with IOP elevation caused by an anterior chamber pigmentary disease. The advent of mice for glaucoma research is already having a significant impact on our understanding of this disease, principally because of the access to genetic manipulation technology and genetics already well established for these animals.
ISSN:0014-4835
1096-0007
DOI:10.1016/j.exer.2008.12.002