Effect of Mass Transport in the Synthesis of Partially Acetylated Dendrimer: Implications for Functional Ligand−Nanoparticle Distributions

Partial acetylation of the amine-terminated poly(amidoamine) dendrimer has been used in the preparation of dendrimer particles conjugated with a wide variety of functional ligands including targeting moieties, therapeutic agents, and dye molecules. The effectiveness of mass transport during the part...

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Bibliographic Details
Published in:Macromolecules 2010-08, Vol.43 (16), p.6577-6587
Main Authors: Mullen, Douglas G, Borgmeier, Emilee L, Fang, Ming, McNerny, Daniel Q, Desai, Ankur, Baker, James R, Orr, Bradford G, Banaszak Holl, Mark M
Format: Article
Language:English
Subjects:
Applied sciences
Chemical modifications
Chemical reactions and properties
Exact sciences and technology
Organic polymers
Physicochemistry of polymers
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Summary:Partial acetylation of the amine-terminated poly(amidoamine) dendrimer has been used in the preparation of dendrimer particles conjugated with a wide variety of functional ligands including targeting moieties, therapeutic agents, and dye molecules. The effectiveness of mass transport during the partial acetylation reaction was found to have a major effect on subsequent distributions of dendrimer−ligand components and to be a major source of inconsistency between batches. This study has broad implications for a wide range of nanoparticle−ligand systems because it demonstrates that conjugates with the same mean ligand−particle ratios can have completely different distribution profiles.
ISSN:0024-9297
1520-5835
DOI:10.1021/ma100663c