Effect of Mass Transport in the Synthesis of Partially Acetylated Dendrimer: Implications for Functional Ligand−Nanoparticle Distributions

Partial acetylation of the amine-terminated poly(amidoamine) dendrimer has been used in the preparation of dendrimer particles conjugated with a wide variety of functional ligands including targeting moieties, therapeutic agents, and dye molecules. The effectiveness of mass transport during the part...

Full description

Saved in:
Bibliographic Details
Published in:Macromolecules 2010-08, Vol.43 (16), p.6577-6587
Main Authors: Mullen, Douglas G, Borgmeier, Emilee L, Fang, Ming, McNerny, Daniel Q, Desai, Ankur, Baker, James R, Orr, Bradford G, Banaszak Holl, Mark M
Format: Article
Language:English
Subjects:
Applied sciences
Chemical modifications
Chemical reactions and properties
Exact sciences and technology
Organic polymers
Physicochemistry of polymers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-a435t-9287c1f600d8cfe67f2391681aeec5d1cd1beecbb910b1e07efd25b8b60ed50f3
cites cdi_FETCH-LOGICAL-a435t-9287c1f600d8cfe67f2391681aeec5d1cd1beecbb910b1e07efd25b8b60ed50f3
container_end_page 6587
container_issue 16
container_start_page 6577
container_title Macromolecules
container_volume 43
creator Mullen, Douglas G
Borgmeier, Emilee L
Fang, Ming
McNerny, Daniel Q
Desai, Ankur
Baker, James R
Orr, Bradford G
Banaszak Holl, Mark M
description Partial acetylation of the amine-terminated poly(amidoamine) dendrimer has been used in the preparation of dendrimer particles conjugated with a wide variety of functional ligands including targeting moieties, therapeutic agents, and dye molecules. The effectiveness of mass transport during the partial acetylation reaction was found to have a major effect on subsequent distributions of dendrimer−ligand components and to be a major source of inconsistency between batches. This study has broad implications for a wide range of nanoparticle−ligand systems because it demonstrates that conjugates with the same mean ligand−particle ratios can have completely different distribution profiles.
doi_str_mv 10.1021/ma100663c
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3056448</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1835551433</sourcerecordid><originalsourceid>FETCH-LOGICAL-a435t-9287c1f600d8cfe67f2391681aeec5d1cd1beecbb910b1e07efd25b8b60ed50f3</originalsourceid><addsrcrecordid>eNptkc2OFCEUhYnROO3owhcwbEx00QoFVFe7MJnMj07S_iSOa3KLuswwoaEEyqTfwIUrH9EnkXbaHk1c3Uv4OId7DyGPOXvBWcNfroEz1rbC3CEzrho2V51Qd8mMsUbOl81ycUAe5HzNGOdKivvkoOGSN1LKGfl-ai2aQqOl7yBnepEg5DGmQl2g5Qrpp02oJbu8RT5CKg6839Ajg2XjoeBATzAMya0xvaLn69E7A8XFkKmNiZ5NwWxP4OnKXUIYfn778R5CHLdCxiM9cbkk10-_nzwk9yz4jI929ZB8Pju9OH47X314c358tJqDFKrUibqF4bZlbOiMxXZhG7HkbccB0aiBm4H3tev7JWc9R7ZAOzSq7_qW4aCYFYfk9Y3uOPVrHAyGksDrsU4BaaMjOP3vTXBX-jJ-1YKpVsquCjzbCaT4ZcJc9Nplg95DwDhlzev-leJSiIo-v0FNijkntHsbzvQ2Pb1Pr7JP_v7XnvwTVwWe7gDIBrytYRmXbzlRLSt8y4HJ-jpOqQaQ_2P4C1Dvs24</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1835551433</pqid></control><display><type>article</type><title>Effect of Mass Transport in the Synthesis of Partially Acetylated Dendrimer: Implications for Functional Ligand−Nanoparticle Distributions</title><source>American Chemical Society:Jisc Collections:American Chemical Society Read &amp; Publish Agreement 2022-2024 (Reading list)</source><creator>Mullen, Douglas G ; Borgmeier, Emilee L ; Fang, Ming ; McNerny, Daniel Q ; Desai, Ankur ; Baker, James R ; Orr, Bradford G ; Banaszak Holl, Mark M</creator><creatorcontrib>Mullen, Douglas G ; Borgmeier, Emilee L ; Fang, Ming ; McNerny, Daniel Q ; Desai, Ankur ; Baker, James R ; Orr, Bradford G ; Banaszak Holl, Mark M</creatorcontrib><description>Partial acetylation of the amine-terminated poly(amidoamine) dendrimer has been used in the preparation of dendrimer particles conjugated with a wide variety of functional ligands including targeting moieties, therapeutic agents, and dye molecules. The effectiveness of mass transport during the partial acetylation reaction was found to have a major effect on subsequent distributions of dendrimer−ligand components and to be a major source of inconsistency between batches. This study has broad implications for a wide range of nanoparticle−ligand systems because it demonstrates that conjugates with the same mean ligand−particle ratios can have completely different distribution profiles.</description><identifier>ISSN: 0024-9297</identifier><identifier>EISSN: 1520-5835</identifier><identifier>DOI: 10.1021/ma100663c</identifier><identifier>PMID: 21412444</identifier><identifier>CODEN: MAMOBX</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Applied sciences ; Chemical modifications ; Chemical reactions and properties ; Exact sciences and technology ; Organic polymers ; Physicochemistry of polymers</subject><ispartof>Macromolecules, 2010-08, Vol.43 (16), p.6577-6587</ispartof><rights>Copyright © 2010 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><rights>XXXX American Chemical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a435t-9287c1f600d8cfe67f2391681aeec5d1cd1beecbb910b1e07efd25b8b60ed50f3</citedby><cites>FETCH-LOGICAL-a435t-9287c1f600d8cfe67f2391681aeec5d1cd1beecbb910b1e07efd25b8b60ed50f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=23143214$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21412444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mullen, Douglas G</creatorcontrib><creatorcontrib>Borgmeier, Emilee L</creatorcontrib><creatorcontrib>Fang, Ming</creatorcontrib><creatorcontrib>McNerny, Daniel Q</creatorcontrib><creatorcontrib>Desai, Ankur</creatorcontrib><creatorcontrib>Baker, James R</creatorcontrib><creatorcontrib>Orr, Bradford G</creatorcontrib><creatorcontrib>Banaszak Holl, Mark M</creatorcontrib><title>Effect of Mass Transport in the Synthesis of Partially Acetylated Dendrimer: Implications for Functional Ligand−Nanoparticle Distributions</title><title>Macromolecules</title><addtitle>Macromolecules</addtitle><description>Partial acetylation of the amine-terminated poly(amidoamine) dendrimer has been used in the preparation of dendrimer particles conjugated with a wide variety of functional ligands including targeting moieties, therapeutic agents, and dye molecules. The effectiveness of mass transport during the partial acetylation reaction was found to have a major effect on subsequent distributions of dendrimer−ligand components and to be a major source of inconsistency between batches. This study has broad implications for a wide range of nanoparticle−ligand systems because it demonstrates that conjugates with the same mean ligand−particle ratios can have completely different distribution profiles.</description><subject>Applied sciences</subject><subject>Chemical modifications</subject><subject>Chemical reactions and properties</subject><subject>Exact sciences and technology</subject><subject>Organic polymers</subject><subject>Physicochemistry of polymers</subject><issn>0024-9297</issn><issn>1520-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNptkc2OFCEUhYnROO3owhcwbEx00QoFVFe7MJnMj07S_iSOa3KLuswwoaEEyqTfwIUrH9EnkXbaHk1c3Uv4OId7DyGPOXvBWcNfroEz1rbC3CEzrho2V51Qd8mMsUbOl81ycUAe5HzNGOdKivvkoOGSN1LKGfl-ai2aQqOl7yBnepEg5DGmQl2g5Qrpp02oJbu8RT5CKg6839Ajg2XjoeBATzAMya0xvaLn69E7A8XFkKmNiZ5NwWxP4OnKXUIYfn778R5CHLdCxiM9cbkk10-_nzwk9yz4jI929ZB8Pju9OH47X314c358tJqDFKrUibqF4bZlbOiMxXZhG7HkbccB0aiBm4H3tev7JWc9R7ZAOzSq7_qW4aCYFYfk9Y3uOPVrHAyGksDrsU4BaaMjOP3vTXBX-jJ-1YKpVsquCjzbCaT4ZcJc9Nplg95DwDhlzev-leJSiIo-v0FNijkntHsbzvQ2Pb1Pr7JP_v7XnvwTVwWe7gDIBrytYRmXbzlRLSt8y4HJ-jpOqQaQ_2P4C1Dvs24</recordid><startdate>20100824</startdate><enddate>20100824</enddate><creator>Mullen, Douglas G</creator><creator>Borgmeier, Emilee L</creator><creator>Fang, Ming</creator><creator>McNerny, Daniel Q</creator><creator>Desai, Ankur</creator><creator>Baker, James R</creator><creator>Orr, Bradford G</creator><creator>Banaszak Holl, Mark M</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100824</creationdate><title>Effect of Mass Transport in the Synthesis of Partially Acetylated Dendrimer: Implications for Functional Ligand−Nanoparticle Distributions</title><author>Mullen, Douglas G ; Borgmeier, Emilee L ; Fang, Ming ; McNerny, Daniel Q ; Desai, Ankur ; Baker, James R ; Orr, Bradford G ; Banaszak Holl, Mark M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a435t-9287c1f600d8cfe67f2391681aeec5d1cd1beecbb910b1e07efd25b8b60ed50f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Applied sciences</topic><topic>Chemical modifications</topic><topic>Chemical reactions and properties</topic><topic>Exact sciences and technology</topic><topic>Organic polymers</topic><topic>Physicochemistry of polymers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mullen, Douglas G</creatorcontrib><creatorcontrib>Borgmeier, Emilee L</creatorcontrib><creatorcontrib>Fang, Ming</creatorcontrib><creatorcontrib>McNerny, Daniel Q</creatorcontrib><creatorcontrib>Desai, Ankur</creatorcontrib><creatorcontrib>Baker, James R</creatorcontrib><creatorcontrib>Orr, Bradford G</creatorcontrib><creatorcontrib>Banaszak Holl, Mark M</creatorcontrib><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mullen, Douglas G</au><au>Borgmeier, Emilee L</au><au>Fang, Ming</au><au>McNerny, Daniel Q</au><au>Desai, Ankur</au><au>Baker, James R</au><au>Orr, Bradford G</au><au>Banaszak Holl, Mark M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Mass Transport in the Synthesis of Partially Acetylated Dendrimer: Implications for Functional Ligand−Nanoparticle Distributions</atitle><jtitle>Macromolecules</jtitle><addtitle>Macromolecules</addtitle><date>2010-08-24</date><risdate>2010</risdate><volume>43</volume><issue>16</issue><spage>6577</spage><epage>6587</epage><pages>6577-6587</pages><issn>0024-9297</issn><eissn>1520-5835</eissn><coden>MAMOBX</coden><abstract>Partial acetylation of the amine-terminated poly(amidoamine) dendrimer has been used in the preparation of dendrimer particles conjugated with a wide variety of functional ligands including targeting moieties, therapeutic agents, and dye molecules. The effectiveness of mass transport during the partial acetylation reaction was found to have a major effect on subsequent distributions of dendrimer−ligand components and to be a major source of inconsistency between batches. This study has broad implications for a wide range of nanoparticle−ligand systems because it demonstrates that conjugates with the same mean ligand−particle ratios can have completely different distribution profiles.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>21412444</pmid><doi>10.1021/ma100663c</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0024-9297
ispartof Macromolecules, 2010-08, Vol.43 (16), p.6577-6587
issn 0024-9297
1520-5835
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3056448
source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Applied sciences
Chemical modifications
Chemical reactions and properties
Exact sciences and technology
Organic polymers
Physicochemistry of polymers
title Effect of Mass Transport in the Synthesis of Partially Acetylated Dendrimer: Implications for Functional Ligand−Nanoparticle Distributions
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T20%3A44%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Mass%20Transport%20in%20the%20Synthesis%20of%20Partially%20Acetylated%20Dendrimer:%20Implications%20for%20Functional%20Ligand%E2%88%92Nanoparticle%20Distributions&rft.jtitle=Macromolecules&rft.au=Mullen,%20Douglas%20G&rft.date=2010-08-24&rft.volume=43&rft.issue=16&rft.spage=6577&rft.epage=6587&rft.pages=6577-6587&rft.issn=0024-9297&rft.eissn=1520-5835&rft.coden=MAMOBX&rft_id=info:doi/10.1021/ma100663c&rft_dat=%3Cproquest_pubme%3E1835551433%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a435t-9287c1f600d8cfe67f2391681aeec5d1cd1beecbb910b1e07efd25b8b60ed50f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1835551433&rft_id=info:pmid/21412444&rfr_iscdi=true