An experimental model of ischemia in rabbit hindlimb

This study was performed to establish an experimental model of ischemia for the investigation of new treatment modality of limb-threatening ischemia. We produced ischemia in the hindlimbs of 8 New Zealand white rabbits. Under general anesthesia, the left femoral artery was exposed, freed, and excise...

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Bibliographic Details
Published in:Journal of Korean medical science 2001-10, Vol.16 (5), p.630-635
Main Authors: Hong, J H, Bahk, Y W, Suh, J S, Kwak, B K, Shim, H J, Kim, J S, Kim, H S, Moon, Y H, Kim, S J, Chung, J W, Park, J H
Format: Article
Language:English
Subjects:
Angiography
Animals
Blood Pressure
Disease Models, Animal
Hindlimb - blood supply
Ischemia - diagnostic imaging
Ischemia - physiopathology
Male
Rabbits
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Summary:This study was performed to establish an experimental model of ischemia for the investigation of new treatment modality of limb-threatening ischemia. We produced ischemia in the hindlimbs of 8 New Zealand white rabbits. Under general anesthesia, the left femoral artery was exposed, freed, and excised from distal external iliac artery to proximal popliteal and saphenous arteries. And then both hindlimbs were serially examined to assess the ischemia according to the time table until postoperative 6 weeks. We assessed clinical observation, blood pressure, radioisotopic perfusion scan, and angiography. Clinical ischemic changes of the operated feet were observed in 63%. The blood pressure of left calves was measurable on postoperative day 3 (p
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2001.16.5.630