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Neurovascular changes measured by time-of-flight MR angiography in cholesterol-fed rabbits with cortical amyloid β-peptide accumulation

Purpose: To test the hypothesis that narrowing of cranial blood vessels in cholesterol‐fed rabbits is a function of the duration of the high cholesterol diet. Such neurovascular changes, caused by elevated serum cholesterol, are linked to stroke and Alzheimer's disease risk. Materials and Metho...

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Published in:Journal of magnetic resonance imaging 2010-08, Vol.32 (2), p.306-314
Main Authors: Lemieux, Susan K., Smith-Bell, Carrie A., Wells, Jered R, Ezerioha, Nnadozie M., Carpenter, Jeffrey S., Sparks, D. Larry, Schreurs, Bernard G.
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container_title Journal of magnetic resonance imaging
container_volume 32
creator Lemieux, Susan K.
Smith-Bell, Carrie A.
Wells, Jered R
Ezerioha, Nnadozie M.
Carpenter, Jeffrey S.
Sparks, D. Larry
Schreurs, Bernard G.
description Purpose: To test the hypothesis that narrowing of cranial blood vessels in cholesterol‐fed rabbits is a function of the duration of the high cholesterol diet. Such neurovascular changes, caused by elevated serum cholesterol, are linked to stroke and Alzheimer's disease risk. Materials and Methods: Four groups of New Zealand White rabbits were studied. Six were fed a normal diet, 19 were fed a 2% cholesterol diet with 0.12 ppm copper in the drinking water for 8 weeks, 10 weeks, or 12 weeks. Time‐of‐flight (TOF) MR angiography (MRA) at 3 Tesla was used to measure arterial diameters in 11 vessels. Previously published data for amyloid β‐peptide (Aβ) accumulation in the brains measured postmortem were correlated to vessel diameters. Ventricular volumes of rabbits were measured on group‐averaged data. Results: Several vessel diameters decreased with cholesterol diet duration. The posterior communicating arteries showed the largest significant effect. Aβ accumulation was inversely correlated with arterial diameter. Ventricular volumes between the normal diet and 12 weeks cholesterol‐fed groups were not significantly different. Conclusion: Reduction in vessel diameter of medium‐sized vessels but not large vessels was measured in these hypercholesterolemic rabbits. The vessel diameter narrowing and cortical Aβ deposition occurred before measurable ventricular enlargement. J. Magn. Reson. Imaging 2010;32:306–314. © 2010 Wiley‐Liss, Inc.
doi_str_mv 10.1002/jmri.22244
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Larry</creatorcontrib><creatorcontrib>Schreurs, Bernard G.</creatorcontrib><title>Neurovascular changes measured by time-of-flight MR angiography in cholesterol-fed rabbits with cortical amyloid β-peptide accumulation</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose: To test the hypothesis that narrowing of cranial blood vessels in cholesterol‐fed rabbits is a function of the duration of the high cholesterol diet. Such neurovascular changes, caused by elevated serum cholesterol, are linked to stroke and Alzheimer's disease risk. Materials and Methods: Four groups of New Zealand White rabbits were studied. Six were fed a normal diet, 19 were fed a 2% cholesterol diet with 0.12 ppm copper in the drinking water for 8 weeks, 10 weeks, or 12 weeks. Time‐of‐flight (TOF) MR angiography (MRA) at 3 Tesla was used to measure arterial diameters in 11 vessels. 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subjects Alzheimer's disease
Amyloid beta-Peptides - chemistry
amyloid β-peptide
angiography
Animal Feed
Animals
Blood Vessels - pathology
Cerebral Cortex - metabolism
Cerebral Cortex - pathology
cerebrovascular
cholesterol
Cholesterol - chemistry
copper
Diet
Dietary Fats - metabolism
Disease Models, Animal
Humans
Magnetic Resonance Angiography - methods
Male
MRI
rabbit
Rabbits
Risk
stroke
Stroke - pathology
TOF-MRA
title Neurovascular changes measured by time-of-flight MR angiography in cholesterol-fed rabbits with cortical amyloid β-peptide accumulation
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