The Giant Protein Titin: A Regulatory Node That Integrates Myocyte Signaling Pathways

Titin, the largest protein in the human body, is well known as a molecular spring in muscle cells and scaffold protein aiding myofibrillar assembly. However, recent evidence has established another important role for titin: that of a regulatory node integrating, and perhaps coordinating, diverse sig...

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Bibliographic Details
Published in:The Journal of biological chemistry 2011-03, Vol.286 (12), p.9905-9912
Main Authors: Krüger, Martina, Linke, Wolfgang A.
Format: Article
Language:English
Subjects:
Animals
Cardiac Hypertrophy
Cardiac Muscle
Cardiomegaly - genetics
Cardiomegaly - metabolism
Cardiomegaly - pathology
Connectin
Contractile Protein
Cytoskeleton
Gene Expression Regulation
Humans
Minireviews
Muscle Proteins - genetics
Muscle Proteins - metabolism
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
Myofibrils - genetics
Myofibrils - metabolism
Phosphorylation - genetics
Protein Kinase A (PKA)
Protein Kinase C (PKC)
Protein Kinase G (PKG)
Protein Kinases - genetics
Protein Kinases - metabolism
Signal Transduction
Skeletal Muscle
Titin
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Summary:Titin, the largest protein in the human body, is well known as a molecular spring in muscle cells and scaffold protein aiding myofibrillar assembly. However, recent evidence has established another important role for titin: that of a regulatory node integrating, and perhaps coordinating, diverse signaling pathways, particularly in cardiomyocytes. We review key findings within this emerging field, including those related to phosphorylation of the titin springs, and also discuss how titin participates in hypertrophic gene regulation and protein quality control.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.R110.173260