Improved oral bioavailability in rats of SR13668, a novel anti-cancer agent

Purpose SR13668, a bis-indole with potent activity in vitro and in vivo against various cancers and promising cancer chemopreventive activity, was found to have very low oral bioavailability, 

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Bibliographic Details
Published in:Cancer chemotherapy and pharmacology 2011-05, Vol.67 (5), p.995-1006
Main Authors: Green, Carol E., Swezey, Robert, Bakke, James, Shinn, Walter, Furimsky, Anna, Bejugam, Naveen, Shankar, Gita N., Jong, Ling, Kapetanovic, Izet M.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Antineoplastic agents
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacokinetics
Biological and medical sciences
Biological Availability
Cancer Research
Carbazoles - administration & dosage
Carbazoles - pharmacokinetics
Female
Humans
In Vitro Techniques
Injections, Intravenous
Male
Medical sciences
Medicine
Medicine & Public Health
Microsomes, Liver - metabolism
Oncology
Original Article
Pharmacology. Drug treatments
Pharmacology/Toxicology
Pilot Projects
Rats
Rats, Sprague-Dawley
Sex Factors
Solubility
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Description
Summary:Purpose SR13668, a bis-indole with potent activity in vitro and in vivo against various cancers and promising cancer chemopreventive activity, was found to have very low oral bioavailability, 
ISSN:0344-5704
1432-0843
1432-0843
DOI:10.1007/s00280-010-1395-9