Distinctive microRNA expression profiles in CD34+ bone marrow cells from patients with myelodysplastic syndrome

MicroRNAs (miRNAs) are small non-coding RNAs functioning as regulators of hematopoiesis. Their differential expression patterns have been linked with various pathological processes originating from hematopoietic stem cells (HSCs). However, limited information is available regarding the role of miRNA...

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Bibliographic Details
Published in:European journal of human genetics : EJHG 2011-03, Vol.19 (3), p.313-319
Main Authors: Dostalova Merkerova, Michaela, Krejcik, Zdenek, Votavova, Hana, Belickova, Monika, Vasikova, Alzbeta, Cermak, Jaroslav
Format: Article
Language:English
Subjects:
631/208/191/2018
692/698/1543/233/1343
692/699/1541
Acute myeloid leukemia
Adult
Aged
Analysis of Variance
Antigens, CD34 - analysis
Antigens, CD34 - immunology
Apoptosis
Bioinformatics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Blast cells
Blood transfusions
Bone marrow
Cancer
CD34 antigen
Chromosome 14
Chromosomes
Clonal deletion
Cytogenetics
Down-Regulation
Female
Fundamental and applied biological sciences. Psychology
Gene Deletion
Gene Expression
Gene Expression Profiling
General aspects. Genetic counseling
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Hematologic and hematopoietic diseases
Hematology
Hematopoiesis
Hematopoietic stem cells
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - immunology
Hemopoiesis
Human Genetics
Humans
Leukemia
Leukemia, Myeloid, Acute - metabolism
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical genetics
Medical sciences
Microarray Analysis
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
Middle Aged
MiRNA
Molecular and cellular biology
Multigene Family
Myelodysplastic syndrome
Myelodysplastic Syndromes - genetics
Myelodysplastic Syndromes - pathology
Myeloid leukemia
non-coding RNA
Patients
Refractory anemia
Stem cells
Up-Regulation
Young Adult
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Summary:MicroRNAs (miRNAs) are small non-coding RNAs functioning as regulators of hematopoiesis. Their differential expression patterns have been linked with various pathological processes originating from hematopoietic stem cells (HSCs). However, limited information is available regarding the role of miRNAs in myelodysplastic syndrome (MDS). Using miRNA arrays, we measured expression of 1,145 miRNAs in CD34+ bone marrow cells obtained from 39 MDS and acute myeloid leukemia (AML) evolved from MDS patients, and compared them with those of six healthy donors. Differential miRNA expression was analyzed and a panel of upregulated ( n =13) and downregulated ( n =9) miRNAs were found ( P
ISSN:1018-4813
1476-5438
DOI:10.1038/ejhg.2010.209