Toll-like receptor 2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population

Sarcoidosis is a systemic inflammatory disease characterized by the formation of non-caseating granulomas, with varied clinical manifestations. The common etiology of sarcoidosis is uncertain, but it is thought to be triggered by an exogenous antigenic stimulus, such as some bacterial proteins. Toll...

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Bibliographic Details
Published in:Molecular vision 2011-03, Vol.17, p.731-736
Main Authors: Sato, Mayuki, Kawagoe, Tatsukata, Meguro, Akira, Ota, Masao, Katsuyama, Yoshihiko, Ishihara, Mami, Namba, Kenichi, Kitaichi, Nobuyoshi, Morimoto, Shin-ichiro, Kaburaki, Toshikatsu, Ando, Yasutaka, Takenaka, Shinobu, Ohno, Shigeaki, Inoko, Hidetoshi, Mizuki, Nobuhisa
Format: Article
Language:English
Subjects:
Asian Continental Ancestry Group - genetics
Case-Control Studies
Etiology
Gene frequency
Gene Frequency - genetics
Gene polymorphism
Genetic diversity
Genetic Predisposition to Disease
Genetics, Population
Granuloma
Haplotypes
Humans
Immune response
Inflammation - complications
Inflammation - genetics
Inflammatory diseases
Japan
Linkage Disequilibrium - genetics
Polymorphism, Single Nucleotide - genetics
Sarcoidosis
Sarcoidosis - complications
Sarcoidosis - genetics
Single-nucleotide polymorphism
TLR2 protein
Toll-Like Receptor 2 - genetics
Toll-like receptors
Vision
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Summary:Sarcoidosis is a systemic inflammatory disease characterized by the formation of non-caseating granulomas, with varied clinical manifestations. The common etiology of sarcoidosis is uncertain, but it is thought to be triggered by an exogenous antigenic stimulus, such as some bacterial proteins. Toll-like receptors (TLRs) recognize microbial components and elicit innate as well as adaptive immune responses. It has been reported that polymorphisms in TLR2 might be important in a small group of Caucasian sarcoidosis patients. The present study aimed to establish whether these findings are relevant to the Japanese population. We genotyped 5 single-nucleotide polymorphisms (SNPs) in TLR2 and assessed the allelic diversity between 257 Japanese sarcoidosis patients and 193 Japanese healthy controls. No significant differences in the frequency of TLR2 alleles and haplotypes in the sarcoidosis cases were found in comparison with the controls. However, marginal associations were observed for TLR2 at rs3804099 and rs3804100 in sarcoidosis patients with cutaneous manifestations. Our results suggest that TLR2 polymorphisms are not significantly related to the pathogenesis of sarcoidosis in the Japanese population.
ISSN:1090-0535
1090-0535