Pemphigoid gestationis

A 39-year-old woman in the 39th week of her fifth pregnancy presented with severe itching. In recent weeks she had developed an increasingly itchy rash on her trunk and arms. Upon examination we observed multiple erythematous plaques and vesicles. Histological examinations of two skin biopsies confi...

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Bibliographic Details
Published in:BMJ case reports 2011-02, Vol.2011 (feb04 1), p.bcr0120102623-bcr0120102623
Main Authors: Lardenoije, Céline M J G, Water, Marije van de, Mertens, Helena J M M, Gondrie, Ed T C M
Format: Article
Language:English
Subjects:
Abdomen
Adult
Antibodies
Antigens
Disease
Europe (West)
Female
Fetuses
Humans
Obstetrics
Patients
Pemphigoid Gestationis - diagnosis
Postpartum period
Pregnancy
Pruritus - etiology
Rare Disease
White
Womens health
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Summary:A 39-year-old woman in the 39th week of her fifth pregnancy presented with severe itching. In recent weeks she had developed an increasingly itchy rash on her trunk and arms. Upon examination we observed multiple erythematous plaques and vesicles. Histological examinations of two skin biopsies confirmed the diagnosis of pemphigoid gestationis. Because the patient's complaints worsened we decided to deliver the baby, and as it was in transverse lie this was by caesarean section. A healthy son without rash was born. Although pemphigoid gestationis occurs in only 1 in 50 000 pregnancies, it is very important to be aware of this condition when a pregnant woman has itching. Not recognising pemphigoid gestationis may lead to inadequate maternal treatment and possible preterm birth and neonatal pemphigoid gestationis.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr.01.2010.2623