CCR6 as a mediator of immunity in the lung and gut

Chemokines are key mediators of leukocyte recruitment during pathogenic insult and also play a prominent role in homeostasis. While most chemokine receptors bind to multiple chemokines, CCR6 is unique in that this receptor is one of only a few that can bind only a single chemokine ligand, CCL20. CCR...

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Bibliographic Details
Published in:Experimental cell research 2011-03, Vol.317 (5), p.613-619
Main Authors: Ito, Toshihiro, Carson, William F., Cavassani, Karen A., Connett, Judith M., Kunkel, Steven L.
Format: Article
Language:English
Subjects:
Animals
Antigen presentation
CCR6
Cellular biology
Chemokines - immunology
Cytokines
Dendritic cell
Homeostasis
Humans
Immunity
Innate immunity
Intestinal Mucosa - cytology
Intestinal Mucosa - immunology
Lung - cytology
Lung - immunology
Mucosal immunity
Pathogenesis
Receptors, CCR6 - immunology
T cell receptors
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Summary:Chemokines are key mediators of leukocyte recruitment during pathogenic insult and also play a prominent role in homeostasis. While most chemokine receptors bind to multiple chemokines, CCR6 is unique in that this receptor is one of only a few that can bind only a single chemokine ligand, CCL20. CCR6 is an important receptor that is involved in regulating several aspects of mucosal immunity, including the ability to mediate the recruitment of immature dendritic cells (DCs) and mature DCs, and professional antigen presenting cells (APCs) to the sites of epithelial inflammation. Further, CCR6 mediates the homing of both CD4+ T (T-helper; Th) cells and DCs to the gut mucosal lymphoid tissue. DCs, which are known to be essential immune cells in innate immunity and in the initiation of adaptive immunity, play a central role in initiating a primary immune response. Herein, we summarize the role of CCR6 in immune responses at epithelial and mucosal sites in both the lung and gut based on a review of the current literature.
ISSN:0014-4827
1090-2422
DOI:10.1016/j.yexcr.2010.12.018