Challenges in the Diagnosis of 2009 H1N1 in a Lung Transplant Patient and the Long-Term Implications for Prevention and Treatment: A Case Report

Abstract Although respiratory viral infections have been associated with acute rejection and bronchiolitis obliterans syndrome, the long-term impact of the novel pandemic influenza A (2009 H1N1) virus on lung transplant patients has not been defined. We describe the diagnostic challenges and long-te...

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Bibliographic Details
Published in:Transplantation proceedings 2010-12, Vol.42 (10), p.4295-4299
Main Authors: Davis, C.S, Deburghgraeve, C.R, Yong, S, Parada, J.P, Palladino-Davis, A.G, Lowery, E, Gagermeier, J, Fisichella, P.M
Format: Article
Language:English
Subjects:
Adult
Antiviral Agents - therapeutic use
Biological and medical sciences
Biopsy
Cystic Fibrosis - surgery
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Influenza A Virus, H1N1 Subtype - isolation & purification
Influenza, Human - diagnosis
Influenza, Human - drug therapy
Influenza, Human - pathology
Influenza, Human - prevention & control
Lung Transplantation
Medical sciences
Miscellaneous
Public health. Hygiene
Public health. Hygiene-occupational medicine
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue, organ and graft immunology
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Summary:Abstract Although respiratory viral infections have been associated with acute rejection and bronchiolitis obliterans syndrome, the long-term impact of the novel pandemic influenza A (2009 H1N1) virus on lung transplant patients has not been defined. We describe the diagnostic challenges and long-term consequences of 2009 H1N1 infection in a lung transplant patient, discuss the potential implications for prevention and treatment, and conclude that even timely antiviral therapy may be insufficient to prevent long-term morbidity.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2010.09.028