In Vitro Characterization of GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease with a Favorable Resistance Profile

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Published in:Antimicrobial Agents and Chemotherapy 2011-04, Vol.55 (4), p.1366-1376
Main Authors: CALLEBAUT, Christian, STRAY, Kirsten, MULATO, Andrew, HATADA, Marcos, PRISKICH, Tina, PARKIN, Neil, SWAMINATHAN, Swami, LEE, William, HE, Gong-Xin, LIANHONG XU, CIHLAR, Tomas, TSAI, Luong, WILLIAMS, Matt, YANG, Zheng-Yu, CANNIZZARO, Carina, LEAVITT, Stephanie A, XIAOHONG LIU, KELLY WANG, MURRAY, Bernard P
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
antiretroviral agents
Antiviral Agents
Biological and medical sciences
Calorimetry
CD4 antigen
CD4-Positive T-Lymphocytes - drug effects
Cells, Cultured
Crystallography, X-Ray
Cytotoxicity
HEK293 Cells
Hep G2 Cells
HIV Protease
HIV Protease - chemistry
HIV Protease - metabolism
HIV Protease Inhibitors
HIV Protease Inhibitors - chemistry
HIV Protease Inhibitors - pharmacology
HIV-1 - drug effects
Human immunodeficiency virus 1
Humans
Kinetics
Liver
Lymphocytes T
Macrophages
Medical sciences
Metabolism
Molecular Structure
Organophosphonates
Organophosphonates - chemistry
Pharmacokinetics
Pharmacology. Drug treatments
Proteasome Endopeptidase Complex - metabolism
Proteinase
Ritonavir
Serum proteins
Thermodynamics
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01183-10