Innate immune sensing of DNA viruses

Abstract DNA viruses are a significant contributor to human morbidity and mortality. The immune system protects against viral infections through coordinated innate and adaptive immune responses. While the antigen-specific adaptive mechanisms have been extensively studied, the critical contributions...

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 2011-03, Vol.411 (2), p.153-162
Main Authors: Rathinam, Vijay A.K, Fitzgerald, Katherine A
Format: Article
Language:English
Subjects:
DNA Viruses - immunology
Humans
Immunity, Innate
Infectious Disease
Inflammasome
Innate immunity
Interferon
Receptors, Immunologic - physiology
Toll like receptors
Virus
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Summary:Abstract DNA viruses are a significant contributor to human morbidity and mortality. The immune system protects against viral infections through coordinated innate and adaptive immune responses. While the antigen-specific adaptive mechanisms have been extensively studied, the critical contributions of innate immunity to anti-viral defenses have only been revealed in the very recent past. Central to these anti-viral defenses is the recognition of viral pathogens by a diverse set of germ-line encoded receptors that survey nearly all cellular compartments for the presence of pathogens. In this review, we discuss the recent advances in the innate immune sensing of DNA viruses and focus on the recognition mechanisms involved.
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2011.02.003