Impaired Virulence and In Vivo Fitness of Colistin-Resistant Acinetobacter baumannii

Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in vitro development of resistance to colistin. The colistin-resistant strain has lower affinity for colistin, reduced in vivo fitness (competition index, .016), and decreased virul...

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Bibliographic Details
Published in:The Journal of infectious diseases 2011-02, Vol.203 (4), p.545-548
Main Authors: López-Rojas, Rafael, Domínguez-Herrera, Juan, McConnell, Michael J., Docobo-Peréz, Fernando, Smani, Younes, Fernández-Reyes, María, Rivas, Luis, Pachón, Jerónimo, McConnell, Mechael J., Samani, Younes, Ferníndez-Reyes, María
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Acinetobacter baumannii - drug effects
Acinetobacter baumannii - pathogenicity
Acinetobacter Infections - microbiology
Acinetobacter Infections - mortality
Animals
Anti-Bacterial Agents - pharmacology
Antibiotics
Antimicrobials
BACTERIA
Bacterial Proteins - genetics
Bacteriology
Biological and medical sciences
Colistin - pharmacology
Disease Models, Animal
Drug Resistance, Bacterial
Female
Fundamental and applied biological sciences. Psychology
Genetic mutation
Infections
Infectious diseases
Inoculum
Lethal dose
Major and Brief Reports
Medical sciences
Mice
Mice, Inbred C57BL
Microbiology
Miscellaneous
Mortality
Mutation
Peritonitis - microbiology
Peritonitis - mortality
Sepsis - microbiology
Sepsis - mortality
Survival Analysis
Transcription Factors - genetics
Type collections
Virulence
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Summary:Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in vitro development of resistance to colistin. The colistin-resistant strain has lower affinity for colistin, reduced in vivo fitness (competition index, .016), and decreased virulence, both in terms of mortality (0% lethal dose, 6.9 vs 4.9 log colony-forming units) and survival in a mouse model of peritoneal sepsis. These results may explain the low incidence and dissemination of colistin resistance in A. baumannii in clinical settings.
ISSN:0022-1899
1537-6613
0022-1899
1537-6613
DOI:10.1093/infdis/jiq086