Presynaptic Facilitation by Neuropeptide Signaling Mediates Odor-Driven Food Search

Internal physiological states influence behavioral decisions. We have investigated the underlying cellular and molecular mechanisms at the first olfactory synapse for starvation modulation of food-search behavior in Drosophila. We found that a local signal by short neuropeptide F (sNPF) and a global...

Full description

Saved in:
Bibliographic Details
Published in:Cell 2011-04, Vol.145 (1), p.133-144
Main Authors: Root, Cory M., Ko, Kang I., Jafari, Amir, Wang, Jing W.
Format: Article
Language:English
Subjects:
Animals
Arthropod Antennae - metabolism
Calcium imaging
Drosophila
Drosophila - physiology
Drosophila Proteins - metabolism
Female
Food
Insulin
Molecular modelling
Neurons
Neuropeptide F
Neuropeptides
Neuropeptides - metabolism
Odorant receptors
Odorants
Olfactory thresholds
Receptors, Neuropeptide - metabolism
Receptors, Odorant - metabolism
Sensory Receptor Cells - metabolism
Signal Transduction
Starvation
Starvation - metabolism
Synapses
Synapses - metabolism
Transcription
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Internal physiological states influence behavioral decisions. We have investigated the underlying cellular and molecular mechanisms at the first olfactory synapse for starvation modulation of food-search behavior in Drosophila. We found that a local signal by short neuropeptide F (sNPF) and a global metabolic cue by insulin are integrated at specific odorant receptor neurons (ORNs) to modulate olfactory sensitivity. Results from two-photon calcium imaging show that starvation increases presynaptic activity via intraglomerular sNPF signaling. Expression of sNPF and its receptor (sNPFR1) in Or42b neurons is necessary for starvation-induced food-search behavior. Presynaptic facilitation in Or42b neurons is sufficient to mimic starvation-like behavior in fed flies. Furthermore, starvation elevates the transcription level of sNPFR1 but not that of sNPF, and insulin signaling suppresses sNPFR1 expression. Thus, starvation increases expression of sNPFR1 to change the odor map, resulting in more robust food-search behavior. [Display omitted] ► Starvation reshapes olfactory representation in the antennal lobe ► Activation of sNPF receptors upon starvation sensitizes select sensory neurons ► Insulin is a global satiety signal to suppress sNPFR1 expression ► Starvation modulation of Or42b sensory neurons promotes food-search behavior
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2011.02.008