Role of ultrasound, clinical and scintigraphyc parameters to predict malignancy in thyroid nodule

This study aimed to evaluate clinical, laboratory, ultrasound (US) and scintigraphyc parameters in thyroid nodule and to develop an auxiliary model for clinical application in the diagnosis of malignancy. We assessed 143 patients who were surgically treated at a single center, 65% (93) benign vs. 35...

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Bibliographic Details
Published in:Head & neck oncology 2011-03, Vol.3 (1), p.17-17, Article 17
Main Authors: Maia, Frederico F R, Matos, Patrícia S, Silva, Bradley P, Pallone, Ana T, Pavin, Elizabeth J, Vassallo, José, Zantut-Wittmann, Denise E
Format: Article
Language:English
Subjects:
Adult
Age
Cancer
Clinical medicine
Diagnosis
Diagnosis, Ultrasonic
Female
Gender
Humans
Hypothyroidism
Male
Medical diagnosis
Middle Aged
Radioisotope scanning
Retrospective Studies
Statistical analysis
Thyroid cancer
Thyroid diseases
Thyroid gland
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - pathology
Thyroid Nodule - diagnosis
Thyroid Nodule - diagnostic imaging
Thyroid Nodule - pathology
Ultrasonography
Variables
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Summary:This study aimed to evaluate clinical, laboratory, ultrasound (US) and scintigraphyc parameters in thyroid nodule and to develop an auxiliary model for clinical application in the diagnosis of malignancy. We assessed 143 patients who were surgically treated at a single center, 65% (93) benign vs. 35% (50) malignant lesions at final histology (1998-2008). The clinical, laboratory, scintigraphyc and US features were compared and a prediction model was designed after the multivariate analysis. There were no differences in gender, serum TSH and FT4 levels, thyroid auto-antibodies (TAb), thyroid dysfunction and scintigraphyc results (P=0.33) between benign and malignant nodule groups. The sonographic study showed differences when the presence of suspected characteristics was found in the nodules of the malignant lesions group, such as: microcalcifications, central flow, border irregularity and hypoechogenicity. After the multivariate analysis the model obtained showed age (>39 years), border irregularity, microcalcifications and nodule size over 2 cm as predictive factors of malignancy, featuring 81.7% of accuracy. This study confirmed a significant increase of risk for malignancy in patients of over 39 years and with suspicious features at US.
ISSN:1758-3284
1758-3284
DOI:10.1186/1758-3284-3-17