Increased peripheral blood expression of electron transport chain genes in bipolar depression

Beech RD, Lowthert L, Leffert JJ, Mason PN, Taylor MM, Umlauf S, Lin A, Lee JY, Maloney K, Muralidharan A, Lorberg B, Zhao H, Newton SS, Mane S, Epperson CN, Sinha R, Blumberg H, Bhagwagar Z. Increased peripheral blood expression of electron transport chain genes in bipolar depression.
Bipolar Disor...

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Published in:Bipolar disorders 2010-12, Vol.12 (8), p.813-824
Main Authors: Beech, Robert D, Lowthert, Lori, Leffert, Janine J, Mason, Portia N, Taylor, Mary M, Umlauf, Sheila, Lin, Aiping, Lee, Ji Young, Maloney, Kathleen, Muralidharan, Anjana, Lorberg, Boris, Zhao, Hongyu, Newton, Samuel S, Mane, Shrikant, Epperson, C Neill, Sinha, Rajita, Blumberg, Hilary, Bhagwagar, Zubin
Format: Article
Language:English
Subjects:
Adult
bipolar disorder
Bipolar Disorder - blood
Bipolar Disorder - genetics
Down-Regulation
Electron Transport Chain Complex Proteins - blood
Electron Transport Chain Complex Proteins - genetics
Female
gene expression
Gene Expression Profiling
Humans
Indexing in process
Male
microarray
Middle Aged
mitochondria
Oligonucleotide Array Sequence Analysis
oxidative phosphorylation
qRT-PCR
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - metabolism
Up-Regulation
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Summary:Beech RD, Lowthert L, Leffert JJ, Mason PN, Taylor MM, Umlauf S, Lin A, Lee JY, Maloney K, Muralidharan A, Lorberg B, Zhao H, Newton SS, Mane S, Epperson CN, Sinha R, Blumberg H, Bhagwagar Z. Increased peripheral blood expression of electron transport chain genes in bipolar depression.
Bipolar Disord 2010: 12: 813–824. © 2010 The Authors.Journal compilation © 2010 John Wiley & Sons A/S. Objective:  To identify specific genetic pathways showing altered expression in peripheral blood of depressed subjects with bipolar disorder (BPD). Methods:  Illumina Sentrix BeadChip (Human‐6v2) microarrays containing >48,000 transcript probes were used to measure levels of gene expression in peripheral blood from 20 depressed subjects with BPD and in 15 healthy control subjects. Quantitative real‐time reverse transcription polymerase chain reaction (qRT‐PCR) was used to confirm a subset of these differences. Results:  A total of 1,180 genes were differentially expressed between subjects with BPD and healthy controls (fold‐change >1.3, false discovery rate‐corrected p 
ISSN:1398-5647
1399-5618
DOI:10.1111/j.1399-5618.2010.00882.x